Abstract

Expression of cell death regulators RIPK-1 and RIPK-3 in mouse and human hair follicle structures was studied by immunohistochemistry. At anagen and catagen stages of mouse hair follicle, RIPK-1+ cells were located in the inner root sheath, whereas RIPK-3+ cells were found in the inner and outer root sheath, dermal papilla, and interfollicular epidermis. RIPK-1 expression intensity was low in the early anagen and increased as mature anagen and catagen approached. RIPK-1+ and RIPK-3+ cells were also found in human hair follicle. It is assumed that the role of necroptosis markers in hair follicle life activity is independent of programmed cell death and that they may have yet unknown functions and take part in noncanonical signal cascades.

中文翻译：

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蛋白激酶RIPK-1和RIPK-3在小鼠和人毛囊中的表达

摘要

通过免疫组织化学研究了细胞死亡调节剂RIPK-1和RIPK-3在小鼠和人毛囊结构中的表达。在小鼠毛囊的生长期和退行期，RIPK-1 +细胞位于内根鞘中，而RIPK-3 +细胞位于内根鞘和外根鞘，真皮乳头和小泡间表皮中。RIPK-1的表达强度在早期的生长期低，并随着成熟的生长期和后代接近而增加。在人的毛囊中也发现了RIPK-1 +和RIPK-3 +细胞。假定坏死病标记物在毛囊生活活动中的作用与程序性细胞死亡无关，并且它们可能具有未知的功能，并参与非规范的信号级联反应。