Deep eutectic solvents (DES) have revealed the ability to promote the aggregation of amphiphiles in solution. With a brief overview on the self-assembly of amphiphilic substances in protic/aprotic, polar/non-polar solvents, ionic liquids (ILs), and deep eutectic solvents, we herein report the aggregation behavior of a star block (4- arm ) ethylene oxide (EO)-propylene oxide (PO) block copolymer (5 %w/v) tetronic T1304 in the presence of different DESs [ChCl: urea, ChCl: ethylene glycol (EG), ChCl: glycerol (Gly), ChCl: malonic acid (MA), ChCl: glutaric acid (GA), and ChCl: oxalic acid (OA)] in varying aqueous molar ratio solution. From high-sensitivity differential scanning calorimetry (HSDSC), surface tension (S.T.), small-angle neutron scattering (SANS), and dynamic light scattering (DLS), we present for the first time the self-aggregation and size distribution profile of amphiphilic tetronic T1304 in DES-water mixture system. The solubility of poorly water-soluble drug, quercetin (QN), was also checked in 5 %w/v copolymeric micelles and in presence of different DESs using UV-Visible spectroscopy. The presence of various DESs alter the micellization and micellar characteristics and such observed behavior are due to the favorable interactions that support the self-assembly in DES-water solvent mixture which is further elucidated by the molecular simulation study using the Gauss View 5.0.9. Graphical abstract Schematic illustration portraying the favorable physicochemical characterization leading to the micellization and depicting enhanced drug solubilization efficiency of optimized T1304-DES mixture.

中文翻译：

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DES-水混合物中两亲星形嵌段共聚物的胶束特性

深共熔溶剂 (DES) 已显示出促进溶液中两亲物聚集的能力。通过对质子/非质子、极性/非极性溶剂、离子液体 (IL) 和深共晶溶剂中两亲物质的自组装的简要概述，我们在此报告了星形块（4 臂）的聚集行为环氧乙烷 (EO)-环氧丙烷 (PO) 嵌段共聚物 (5 %w/v) tetronic T1304 在不同 DES [ChCl: 尿素, ChCl: 乙二醇 (EG), ChCl: 甘油 (Gly), ChCl:丙二酸 (MA)、ChCl: 戊二酸 (GA) 和 ChCl: 草酸 (OA)] 在不同的水溶液摩尔比溶液中。从高灵敏度差示扫描量热法 (HSDSC)、表面张力 (ST)、小角中子散射 (SANS) 和动态光散射 (DLS)，我们首次展示了 DES-水混合物系统中两亲性 tetronic T1304 的自聚集和尺寸分布曲线。水溶性差的药物槲皮素 (QN) 的溶解度也在 5%w/v 共聚胶束中和在不同 DES 存在下使用紫外-可见光谱进行了检查。各种 DES 的存在改变了胶束化和胶束特性，这种观察到的行为是由于支持 DES-水溶剂混合物中自组装的有利相互作用，使用 Gauss View 5.0.9 的分子模拟研究进一步阐明了这一点。图形摘要示意图描绘了导致胶束化的有利物理化学特征，并描绘了优化的 T1304-DES 混合物的药物增溶效率。