Abstract The antiapoptotic protein Mcl-1, which is an attractive target for cancer treatment, is degraded under nutrient deprivation conditions in different types of cancer. This process sensitizes cancer cells to chemotherapy. It has been found that nutrient deprivation leads to suppression of Mcl-1 synthesis; however, the mechanisms of Mcl-1 degradation under such conditions remain to be elucidated. In this study, we have investigated the contribution of autophagy and proteasomal degradation to the regulation of the level of Mcl-1 protein under nutrient deprivation conditions. We found that these circumstances cause a decrease in the level of Mcl-1 in cancer cells in a macroautophagy-independent manner via proteasomal degradation.

中文翻译：

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营养缺乏以独立于自噬的方式促进 MCL-1 降解

摘要 抗凋亡蛋白 Mcl-1 是癌症治疗的一个有吸引力的靶点，在不同类型的癌症中，在营养缺乏条件下会降解。这个过程使癌细胞对化疗敏感。已经发现营养缺乏会导致 Mcl-1 合成受到抑制；然而，在这种条件下 Mcl-1 降解的机制仍有待阐明。在这项研究中，我们研究了自噬和蛋白酶体降解对营养缺乏条件下 Mcl-1 蛋白水平调节的贡献。我们发现这些情况通过蛋白酶体降解以一种不依赖巨自噬的方式导致癌细胞中 Mcl-1 水平的降低。