Human immunodeficiency virus type 1 (HIV) primary drug resistance mutations (DRMs) influence the long-term therapeutic effects of antiretroviral treatment (ART). Drug-resistance genotyping based on polymerase gene sequences obtained by next-generation sequencing (NGS) was performed using samples from 10 ART-naïve HIV-infected men who have sex with men (MSM; P1-P10) from the acute/early to chronic stage of infection. Three of the 10 subjects exhibited the presence of major (abundance, ≥ 20%) viral populations carrying DRM at early/acute stage that later, at the chronic stage, dropped drastically (V106M) or remained highly abundant (E138A). Four individuals exhibited additional DRMs (M46I/L; I47A; I54M, L100V) as HIV minority populations (abundance, 2–20%) that emerged during the chronic stage but ephemerally.

人类1型免疫缺陷病毒（HIV）原发性耐药突变（DRM）影响抗逆转录病毒治疗（ART）的长期治疗效果。使用由10名未接受过ART感染的男性艾滋病毒感染男性患者（MSM; P1-P10）从急性/早期到慢性进行的样本，基于通过下一代测序（NGS）获得的聚合酶基因序列进行耐药基因分型感染阶段。10名受试者中有3名在早期/急性阶段表现出存在携带DRM的主要（大量，≥20％）病毒种群，后来在慢性阶段，其急剧下降（V106M）或保持高度丰富（E138A）。有四个个体表现出其他DRM（M46I / L； I47A； I54M，L100V）作为HIV少数群体（数量丰富，占2％至20％），这些个体出现在慢性阶段，但短暂出现。