We conducted a systematic review to examine evidence from randomized controlled trials studying the effect of Vitamin D, selenium, or zinc supplementation in human immunodeficiency virus (HIV). An electronic literature search was carried out using Ovid Medline, Embase, CINHAL, Cochrane Center Register of Controlled Trials, Database of Systematic Reviews, Psych Info and PubMed. Eligible articles were assessed for methodological quality on the basis of the adequacy of the randomization process, concealment of allocation, blinding of intervention and outcome, and completeness of follow-up. A total of 24 single supplement trials (Vitamin D, selenium, and zinc) involving 5948 participants were included for this review. Evidence from seven Vitamin D trials showed no damaging or beneficial effect of Vitamin D supplementation on HIV disease progression in HIV-infected adults or children/adolescents. Six of the selenium studies found that providing daily selenium supplementation to HIV-infected adults' increased CD4 cell counts and reduce the risk of diarrhea morbidity and hospital admission rate for HIV-related conditions and opportunistic infection in HIV-infected adults. Evidence from eleven zinc trials showed some evidence of a potential beneficial effect of zinc supplementation on diarrhea morbidity and immune function. However, further research in larger and more diverse populations of HIV patients is required to fully investigate the effect of these nutrients on clinically relevant outcomes in HIV disease, the optimal dose, and the cost-benefit or cost-effectiveness of Vitamin D, selenium, or zinc supplementation.

中文翻译：

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补充维生素D，硒或锌对HIV的影响：系统评价。

我们进行了系统的综述，以研究来自随机对照试验的证据，这些试验研究了维生素D，硒或锌的补充对人体免疫缺陷病毒（HIV）的影响。使用Ovid Medline，Embase，CINHAL，Cochrane对照试验中心注册，系统评价数据库，心理信息和PubMed进行了电子文献检索。根据随机化过程的充分性，分配的隐蔽性，干预和结果的盲目性以及随访的完整性，对符合条件的文章的方法学质量进行评估。总共包括24个单补充试验（维生素D，硒和锌），涉及5948名参与者。七项维生素D试验的证据表明，在感染了HIV的成年人或儿童/青少年中，补充维生素D对HIV疾病的进展没有破坏性或有益的作用。六项硒研究发现，每天向HIV感染的成年人的CD4细胞数量增加提供硒补充，并降低了与HIV相关的疾病和机会性感染的腹泻发病率和住院率，降低了感染HIV的成年人的机会。十一项锌试验的证据表明，补锌对腹泻的发病率和免疫功能具有潜在的有益作用。但是，需要在更大范围和更多种类的HIV患者中进行进一步研究，以全面研究这些营养素对HIV疾病临床相关结局（最佳剂量，