The entire mechanisms by which epigenetic modifiers contribute to the development of pancreatic cancer remain unknown. Although the histone methyltransferase G9a is a promising target in human cancers, its role in pancreatic carcinogenesis has been under-studied. The aim of the study was to examine the role of G9a in pancreatic carcinogenesis by a gene-targeting mouse model.

中文翻译：

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组蛋白甲基转移酶G9a的删除抑制突变克拉斯驱动的胰腺癌发生。

表观遗传修饰物促成胰腺癌发展的全部机制仍然未知。尽管组蛋白甲基转移酶G9a是人类癌症中有希望的靶标，但其在胰腺癌发生中的作用尚未得到充分研究。这项研究的目的是通过靶向基因的小鼠模型研究G9a在胰腺癌发生中的作用。