Circadian rhythm is an internal clock that regulates the cycles of many biological functions. Epidemiological studies have linked aberrant circadian rhythm to an increased susceptibility to cancer and poor patient prognosis. However, there remains a gap in our understanding of genetic variants related to the circadian pathway in renal cell carcinoma (RCC) progression.

中文翻译：

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遗传分析确定了HLF在肾细胞癌中的作用。

昼夜节律是调节许多生物功能周期的内部时钟。流行病学研究已将昼夜节律异常与癌症易感性增加和患者预后不良联系起来。然而，在我们对与肾细胞癌（RCC）进展中的昼夜节律途径相关的遗传变异的理解上仍然存在差距。