The merits of co-sublimation and mechanochemistry as screening techniques for multicomponent crystal formation are compared. Several multicomponent crystals that can be formed both mechanochemically and by sublimation are investigated, allowing for a comparison between the relatively unknown technique of co-sublimation and a well-known, robust solid-state screening methodology. This work aims to determine the general utility and versatility of co-sublimation in the preparation of multicomponent crystals. Co-crystals and salts, as well as their polymorphs, have been investigated, and problems that can arise due to sublimation temperature differences, isomerization, and degradation are discussed. Co-sublimation is shown to be a valuable co-crystallization technique for the discovery and identification of new multicomponent materials.

中文翻译：

---

共升华形成多组分晶体的评估

比较了共升华法和机械化学法作为多组分晶体形成筛选技术的优点。研究了可以通过机械化学的方法和通过升华形成的几种多组分晶体，从而可以将相对未知的共升华技术与众所周知的稳健的固态筛选方法进行比较。这项工作旨在确定共升华在制备多组分晶体中的通用性和通用性。已经研究了共晶体和盐以及它们的多晶型物，并讨论了由于升华温度差，异构化和降解而产生的问题。共升华被证明是发现和鉴定新的多组分材料的一种有价值的共结晶技术。