Programmed cell death (PCD) has been a major area of constantly growing interest over the last three decades. Originally, apoptosis was considered the only mechanistic pathway for PCD, but recently several different pathways (i.e., necroptosis, pyroptosis, ferroptosis) have emerged as important in both normal and pathological conditions.

This review focuses on programmed cell necrosis (i.e., necroptosis) as a promising research direction that will help us in understanding the molecular and cellular processes behind different pathological conditions, such as chronic inflammation, neurodegeneration, and cardiovascular diseases. In addition, we discuss natural and chemical compounds and novel targeted therapies triggering necroptosis to induce cell death in cancer cells to overcome chemoresistance.

在过去的三十年里，程序性细胞死亡 (PCD) 一直是一个不断受到关注的主要领域。最初，细胞凋亡被认为是 PCD 的唯一机制途径，但最近几种不同的途径（即坏死性凋亡、细胞焦亡、铁死亡）在正常和病理条件下都变得很重要。

这篇综述将程序性细胞坏死（即坏死性凋亡）作为一个有前途的研究方向，将帮助我们了解不同病理状况（如慢性炎症、神经退行性疾病和心血管疾病）背后的分子和细胞过程。此外，我们讨论了天然和化学化合物以及触发坏死性凋亡以诱导癌细胞死亡以克服化学抗性的新型靶向疗法。