The organic nanostructures with custom-made properties became increasingly demanding for sundry biological applications. In this insight, some cinnamon nanocrystallites (Cin-NCs) were produced via the pulse laser ablation in liquid (PLAL) approach in different growth solvents (ethanol, methanol and deionized water) at various laser fluences (0–3.2 J.cm⁻²). These as-prepared Cin-NCs were characterized to determine the synergistic properties of the solvents and laser fluences (LFs) on their structures, morphologies, optical absorption and anti-bacterial characteristics. A Q-switched Nd:YAG-1064 nm operated with pulse laser interval of 10 ns and laser frequency of 1 Hz was employed to hit the pure cinnamon target submerged in the desired solvents. The bactericidal effectiveness of the prepared Cin-NCs was tested against Gram-negative and -positive bacterial cultures. The ultraviolent visible spectra of the Cin-NCs displayed two prominent absorption bands and the FTIR spectra showed characteristic bonding vibrations due to different functional groups and bioactive components. The TEM micrograph of the best sample (ablated at the LF of 2.1 J/cm²) manifested the nucleation of Cin-NCs with diverse morphologies. The comparative evaluation of these Cin-NCs produced in different solvents at optimal LF via the PLAL technique was made. Compared to other liquid media, the Cin-NCs made in ethanol exhibited better yield, nanocrystallinity, morphology, absorbance, and bactericidal attributes. It was proven that the physical and anti-bacterial properties of these Cin-NCs can be customized by changing the LFs and types of solvents. The proposed Cin-NCs enclosing active cinnamaldehyde and polyphenols complexes revealed their potency for biomedicine.

具有定制性质的有机纳米结构对杂物生物应用的要求越来越高。在这种见解中，通过在不同生长通量（0–3.2 J.cm ^-2）下在不同的生长溶剂（乙醇，甲醇和去离子水）中通过脉冲液体激光烧蚀（PLAL）方法生产了一些肉桂纳米晶体（Cin-NC）。）。这些制备的Cin-NC的特征在于确定溶剂和激光通量（LF）在其结构，形态，光吸收和抗菌特性方面的协同特性。使用以10 ns的脉冲激光间隔和1 Hz的激光频率操作的Q开关Nd：YAG-1064 nm击中浸没在所需溶剂中的纯肉桂靶。测试了所制备的Cin-NC对革兰氏阴性和阳性细菌培养物的杀菌效力。Cin-NC的紫外可见光谱显示两个突出的吸收带，而FTIR光谱则显示由于不同的官能团和生物活性成分而引起的特征性键合振动。最佳样品的TEM显微照片（以2.1 J / cm ²的LF烧蚀）表现出具有多种形态的Cin-NC的成核。通过PLAL技术对在最佳LF下在不同溶剂中生成的这些Cin-NC进行了比较评估。与其他液体介质相比，用乙醇制得的Cin-NC具有更好的收率，纳米结晶度，形态，吸光度和杀菌特性。事实证明，可以通过改变LF和溶剂类型来定制这些Cin-NC的物理和抗菌特性。拟议的封闭活性肉桂醛和多酚复合物的Cin-NCs显示出其在生物医学中的潜力。