Understanding the principles underlying age-related changes in motion perception is paramount for improving the quality of life and health of older adults. However, the mechanisms underlying age-related alterations in this aspect of vision, which is essential for survival in a dynamic world, still remain unclear. Using optomotor responses to drifting gratings, we investigated age-related changes in motion detection of adult zebrafish (wild-type/AB-strain and achesb55/+ mutants with decreased levels of acetylcholinesterase). Our results pointed out negative optomotor responses that significantly depend on the spatial frequency and contrast level of stimulation, providing supporting evidence for the visual motion-driven aspect of this behavior mainly exhibited by adult zebrafish. Although there were no significant main effects of age and genotype, we found a significant three-way interaction between contrast level, age, and genotype. In the contrast domain, the changes in optomotor responses and thus in the detection of motion direction were age- and genotype-specific. Accordingly, these behavioral findings suggest a strong but complicated relationship between visual motion characteristics and the cholinergic system during neural aging.

中文翻译：

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衰老斑马鱼的视运动反应揭示了视觉运动特征与胆碱能系统之间的复杂关系

了解与年龄相关的运动感知变化的基本原理对于提高老年人的生活质量和健康至关重要。然而，对于在动态世界中生存至关重要的这一视力方面与年龄相关的改变的潜在机制仍不清楚。我们使用对漂移光栅的视运动反应，研究了成年斑马鱼（野生型/AB 型和 achesb55/+ 突变体，乙酰胆碱酯酶水平降低）的运动检测中与年龄相关的变化。我们的结果指出了显着依赖于空间频率和刺激对比度水平的负视运动反应，为主要由成年斑马鱼表现出的这种行为的视觉运动驱动方面提供了支持证据。虽然年龄和基因型没有显着的主效应，我们发现对比度水平、年龄和基因型之间存在显着的三向相互作用。在对比域中，视运动反应的变化以及运动方向检测的变化是年龄和基因型特异性的。因此，这些行为发现表明视觉运动特征与神经衰老过程中的胆碱能系统之间存在强烈但复杂的关系。