Atherosclerosis is no longer a disease attributed mainly to high cholesterol content in the body; it has come to be regarded as a chronic inflammatory disease with an autoimmune component. The purpose of this study was to investigate the effect of the prunin fraction (PF) isolated from the ethanolic extract of Bauhinia variegata against the release of various proinflammatory mediators in rats fed an atherogenic diet. The diet was administered orally to Sprague Dawley rats for 60 days to induce atherosclerosis. The blood serum of the rats was used to estimate the levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), thiobarbituric acid reactive substance, catalase, total cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein using assay kits. Other physical parameters, such as body weight, feed intake, and systolic blood pressure, were also determined during the study. The results showed a significant protective effect of the PF against diet-induced atherosclerosis by decreasing the levels of proinflammatory mediators such as TNF-α and IL-6. Rats treated with PF (20 and 40 mg/kg) showed a change in systolic blood pressure and a reduction in oxidative stress induced by the atherogenic diet. Reduction in body weight and modulation of food intake were observed in PF-treated rats, which indicated atheroprotective, hypolipidemic, and antioxidant effects. The study concludes that the atheroprotective properties of PF are due to effects on the initial phase of plaque formation to thrombus formation. This study may help researchers to find a better alternative for selecting optimal therapies and preventing plaque formation. Future Significance: This article focuses on the molecular mechanisms involved in the evolution of atherosclerotic plaques and different targets that act at the starting stage of the plaque to thrombus formation. This may pave the way for selecting optimal therapies and preventing plaque complications.

动脉粥样硬化不再是主要归因于体内高胆固醇含量的疾病。它已被认为是具有自身免疫成分的慢性炎症性疾病。这项研究的目的是调查从紫荆花的乙醇提取物中分离的李子级分（PF）的作用防止致动脉粥样化饮食中大鼠各种促炎介质的释放。该饮食经口服给予Sprague Dawley大鼠60天以诱导动脉粥样硬化。用大鼠血清评估肿瘤坏死因子-α（TNF-α），白介素-6（IL-6），硫代巴比妥酸反应性物质，过氧化氢酶，总胆固醇，甘油三酸酯，低密度脂蛋白的水平，和使用检测试剂盒的高密度脂蛋白。在研究过程中还确定了其他物理参数，例如体重，采食量和收缩压。结果表明，PF通过降低促炎性介质（如TNF-α和IL-6）的水平，对饮食引起的动脉粥样硬化具有显着的保护作用。用PF（20和40 mg / kg）治疗的大鼠表现出动脉粥样硬化饮食引起的收缩压变化和氧化应激的降低。在PF处理的大鼠中观察到体重减轻和食物摄入调节，这表明其具有抗动脉粥样硬化，降血脂和抗氧化作用。研究得出的结论是，PF的抗动脉粥样硬化特性是由于对斑块形成到血栓形成的初始阶段的影响。这项研究可以帮助研究人员找到更好的替代方法，以选择最佳疗法并预防斑块形成。研究得出的结论是，PF的抗动脉粥样硬化特性是由于对斑块形成到血栓形成的初始阶段的影响。这项研究可以帮助研究人员找到更好的替代方法，以选择最佳疗法并预防斑块形成。研究得出的结论是，PF的抗动脉粥样硬化特性是由于对斑块形成到血栓形成的初始阶段的影响。这项研究可以帮助研究人员找到更好的替代方法，以选择最佳疗法并预防斑块形成。未来的意义：本文重点研究动脉粥样硬化斑块演变过程中涉及的分子机制，以及在斑块开始形成血栓时起作用的不同靶标。这可以为选择最佳疗法和预防牙菌斑并发症铺平道路。