Diallyl disulfide (DADS) is a garlic-derived organo-sulfur compound. This study was carried out to investigate the protective potential, antioxidant, and anti-inflammatory effects of this compound against cyclophosphamide (CP)-induced hepatotoxicity in rats. A single intraperitoneal dose of CP (200 mg/kg) resulted in a significant disturbance in hepatic function and oxidative stress, as well as inflammatory biomarkers. In addition, histopathological examination showed distinct changes and increased expression of proliferating cell nuclear antigen in hepatocytes. On the other hand, daily oral preadministration of DADS (200 mg/kg) for 10 days before the CP dose effectively attenuated the hepatotoxicity caused by CP administration as confirmed by significant amelioration of the aforementioned parameters in rat’s liver. It could be concluded that administration of DADS can diminish CP-induced hepatotoxicity through concurrent upregulation of antioxidant and anti-inflammatory responses that denote its possible potential clinical application against side effects of the CP drug.

二烯丙基二硫化物（DADS）是大蒜衍生的有机硫化合物。进行了这项研究，以研究该化合物对环磷酰胺（CP）诱导的大鼠肝毒性的保护作用，抗氧化剂和抗炎作用。腹膜内单剂量CP（200 mg / kg）导致肝功能和氧化应激以及炎性生物标志物的显着紊乱。另外，组织病理学检查显示肝细胞中增殖细胞核抗原的明显变化和表达增加。另一方面，CP剂量前每日口服DADS（200 mg / kg）10天有效地减轻了CP给药所引起的肝毒性，这一点已通过大鼠肝脏上述参数的明显改善得到证实。