A 14-y-old spayed female Labrador Retriever was presented with an 8-mo history of chronic vomiting. Abdominal ultrasound and gastrointestinal endoscopy revealed a mass protruding into the gastric lumen, with cytologic features suggestive of sarcoma. A partial gastrectomy was performed; the gastric body and antrum were thickened, with a cerebriform appearance of the mucosal surface. Histologic examination revealed a submucosal neoplastic proliferation of fusiform cells variably arranged in irregular bundles and scattered whorls. Fusiform cells strongly reacted to antibodies against vimentin, S100, and neuron-specific enolase; glial fibrillary acidic protein was moderately and multifocally expressed. Pancytokeratin, KIT, α–smooth muscle actin, and desmin were nonreactive. Histologic and immunohistochemical findings suggested a diagnosis of gastric sarcoma with features referable to a non-GIST (gastrointestinal stromal tumor), non–smooth muscle NIMT (non-angiogenic, non-lymphogenic intestinal mesenchymal tumor). The overlying gastric mucosa was thickened by elongated and dilated gastric glands, predominantly lined by intensely periodic acid-Schiff–stained mucous cells. This altered mucosal architecture was suggestive of Ménétrier-like disease. Although this disease has been hypothesized to predispose to gastric adenocarcinoma in dogs, an association with gastric sarcoma has not been documented previously in the veterinary literature, to our knowledge.

一只 14 岁已绝育的雌性拉布拉多犬有 8 个月的慢性呕吐史。腹部超声和胃肠内窥镜检查显示肿块突出到胃腔中，细胞学特征提示肉瘤。进行了部分胃切除术；胃体及胃窦增厚，黏膜表面呈脑状。组织学检查显示黏膜下瘤样增生梭形细胞，不规则排列成不规则束和散在的轮状。梭形细胞对波形蛋白、S100 和神经元特异性烯醇化酶的抗体反应强烈；胶质纤维酸性蛋白中度和多灶性表达。全细胞角蛋白、KIT、α-平滑肌肌动蛋白和结蛋白无反应。组织学和免疫组化结果提示胃肉瘤的诊断，其特征与非 GIST（胃肠道间质瘤）、非平滑肌 NIMT（非血管生成、非淋巴源性肠间充质肿瘤）有关。上覆的胃黏膜被拉长和扩张的胃腺增厚，主要由强烈的高碘酸希夫染色的黏液细胞排列。这种改变的黏膜结构提示 Ménétrier 样疾病。尽管有人假设这种疾病易患狗的胃腺癌，但据我们所知，以前在兽医文献中还没有记录过与胃肉瘤的关联。上覆的胃黏膜被拉长和扩张的胃腺增厚，主要由强烈的高碘酸希夫染色的黏液细胞排列。这种改变的黏膜结构提示 Ménétrier 样疾病。尽管有人假设这种疾病易患狗的胃腺癌，但据我们所知，以前在兽医文献中还没有记录过与胃肉瘤的关联。上覆的胃黏膜被拉长和扩张的胃腺增厚，主要由强烈的高碘酸希夫染色的黏液细胞排列。这种改变的黏膜结构提示 Ménétrier 样疾病。尽管有人假设这种疾病易患狗的胃腺癌，但据我们所知，以前在兽医文献中还没有记录过与胃肉瘤的关联。