Biomaterial with the dual-functions of bone regeneration and antibacterial is a novel therapy for infective bone defects. Three-dimensional (3D)-printed porous titanium (pTi) benefits bone ingrowth, but its microporous structure conducive to bacteria reproduction. Herein, a multifunctional hydrogel was prepared from dynamic supramolecular assembly of sodium tetraborate (Na₂B₄O₇), polyvinyl alcohol (PVA), silver nanoparticles (AgNPs) and tetraethyl orthosilicate (TEOS), and composited with pTi as an implant system. The pTi scaffolds have ideal pore size and porosity matching with bone, while the supramolecular hydrogel endows pTi scaffolds with antibacterial and biological activity. In vitro assessments indicated the 3D composite implant was biocompatible, promoted bone marrow mesenchymal stem cells (BMSCs) proliferation and osteogenic differentiation, and inhibited bacteria, simultaneously. In vivo experiments further demonstrated that the implant showed effective antibacterial ability while promoting bone regeneration. Besides distal femur defect, the innovative scaffolds may also serve as an ideal biomaterial (e.g. dental implants) for other contaminated defects.

具有骨再生和抗菌双重功能的生物材料是一种治疗感染性骨缺损的新型疗法。三维（3D）打印的多孔钛（pTi）有利于骨骼向内生长，但其微孔结构有利于细菌繁殖。在此，由四硼酸钠（Na ₂ B ₄ O _7）的动态超分子组装制备了多功能水凝胶。），聚乙烯醇（PVA），银纳米颗粒（AgNPs）和原硅酸四乙酯（TEOS），并与pTi复合作为植入系统。pTi支架具有理想的孔径和与骨骼相匹配的孔隙率，而超分子水凝胶赋予pTi支架以抗菌和生物活性。体外评估表明3D复合植入物具有生物相容性，可同时促进骨髓间充质干细胞（BMSC）增殖和成骨分化，并抑制细菌。体内实验进一步证明，植入物在促进骨骼再生的同时显示出有效的抗菌能力。除股骨远端缺损外，创新型支架还可作为其他受污染缺损的理想生物材料（例如牙科植入物）。