Aim of the work:

This prospective study was conducted to evaluate the clinical reliability of N-terminal fragment of proB-type natriuretic peptide (NT-proBNP) in identifying patients with cardiotoxicity in the early hours following scorpion sting.

Subjects and methods:

This study involved 483 children aging between 2–17 years who were admitted to Minia University Poisoning Control Center from 1st January 2010 to 31st December 2019 with a history of scorpion sting, and on clinical evaluation symptoms were manifested. All subjects were clinically examined, investigated for NT-proBNP and CPK-MB on admission, 6 h and 24 h post-envenomation; and subjected to 24 h cardiac monitoring with periodic ECG every 6 h.

Results:

Assessment of CPK-MB levels showed a significant increase in all moderate to severe cases 6 h post-envenomation. Assessment of NT-proBNP levels showed a significant increase in all moderate to severe cases on admission and 6 h post-envenomation. Moreover, there was a significant decrease in the NT-proBNP level after 24 h compared with that measured on admission. The sensitivity of NT-proBNP for the diagnosis of myocardial injury at hospital admission was significantly higher than that of CPK-MB.

Conclusion:

NT-proBNP may be a valuable and sensitive laboratory biomarker to predict cardiotoxicity of scorpion sting in the early hours.

中文翻译：

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蝎子蜇伤：proB 型利钠肽的 N 末端片段作为儿科心脏毒性的早期预测因子

工作目标：

这项前瞻性研究旨在评估 proB 型利钠肽 N 末端片段 (NT-proBNP) 在识别蝎子蜇伤后早期心脏毒性患者中的临床可靠性。

题目和方法：

本研究涉及 483 名年龄在 2-17 岁之间的儿童，他们于 2010 年 1 月 1 日至 2019 年 12 月 31 日入住米尼亚大学中毒控制中心，有蝎子蜇伤史，并在临床评估中出现症状。入院时、毒液后 6 小时和 24 小时对所有受试者进行临床检查、NT-proBNP 和 CPK-MB 调查；并接受 24 小时心脏监测，每 6 小时定期进行心电图检查。

结果：

对 CPK-MB 水平的评估显示，毒液后 6 小时，所有中度至重度病例均显着增加。NT-proBNP 水平的评估显示，所有中度至重度病例在入院时和毒液后 6 小时均显着增加。此外，与入院时测量的相比，24 小时后 NT-proBNP 水平显着下降。NT-proBNP对入院心肌损伤诊断的敏感性明显高于CPK-MB。

结论：

NT-proBNP 可能是一种有价值且敏感的实验室生物标志物，可在早期预测蝎子刺痛的心脏毒性。