American Journal of Alzheimer's Disease and other Dementias ( IF 3.4 ) Pub Date : 2020-10-28 , DOI: 10.1177/1533317520965101 Zhizhen Cui 1 , Guizhen Cao 1 , Youyi Wang 1 , Qinghua Ma 2 , Congju Wang 3 , Yong Xu 1 , Hongpeng Sun 1 , Yana Ma 1
Objective:
To find a suitable dividing value to classify cystatin C and evaluate the association between cognition and levels of cystatin C.
Methods:
Using data from the China Health and Retirement Longitudinal Study, We conducted a longitudinal analysis of a prospective cohort of 6,869 middle-aged and older Chinese without cognitive impairment at baseline. Levels of cystatin C were categorized into 2 groups by method of decision tree. Logistic regression models evaluated whether cystatin C was related to cognitive impairment.
Results:
Respondents were categorized as lower levels of cystatin C and higher levels of cystatin C, cut-point was 1.11 mg/L. Higher levels of cystatin C was associated with the odds of cognitive impairment (OR, 1.56; 95% CI, 1.10-2.22) after multivariable adjustment. Respondents with higher levels of cystatin C had worse cognition scores.
Conclusions:
We found a suitable dividing value of cystatin C in middle-aged and older Chinese.