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Improving Nutritional and Functional Quality by Genome Editing of Crops: Status and Perspectives
Frontiers in Plant Science ( IF 5.6 ) Pub Date : 2020-09-15 , DOI: 10.3389/fpls.2020.577313
Hyung-Keun Ku , Sun-Hwa Ha

Genome-editing tools including meganucleases, zinc finger nucleases, transcription activator-like effector nucleases and clustered regularly interspaced short palindromic repeats (CRISPR) system have been applied to improve the quality of staple, oilseed, and horticultural crops with great accuracy and efficiency compared to conventional breeding. In particular, the CRISPR method has proven to be a feasible, cost-effective and versatile tool allowing precise and efficient editing of plant genomes in recent years, showing great potential in crop improvement. Until now, various genome-edited crops with enhanced commercial value have been developed by not only global companies but also small laboratories in universities, suggesting low entry barriers with respect to manpower and capital. In this study, we review the current applications of genome editing technologies to improve the nutritional and functional quality and preferred traits of various crops. Combining this rapidly advancing genome-editing technology and conventional breeding will greatly extend the potential of genome-edited crops and their commercialization.



中文翻译:

通过农作物的基因组编辑改善营养和功能质量:现状和前景

基因组编辑工具包括大范围核酸酶,锌指核酸酶,转录激活因子样效应核酸酶和成簇的规则间隔的短回文重复序列(CRISPR)系统已被用于改善主食,油料种子和园艺作物的质量,与之相比,其准确性和效率都很高。常规繁殖。特别是,CRISPR方法已被证明是一种可行的,具有成本效益的多功能工具,近年来可以精确,高效地编辑植物基因组,在作物改良方面显示出巨大的潜力。到目前为止,不仅全球公司而且大学的小型实验室也开发了具有商业价值的各种基因组编辑作物,这表明在人力和资本方面的准入门槛较低。在这个研究中,我们回顾了基因组编辑技术在改善各种作物的营养和功能质量以及优选性状方面的当前应用。将这种快速发展的基因组编辑技术与常规育种相结合,将大大扩展基因组编辑农作物及其商业化的潜力。

更新日期:2020-10-28
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