Superselective intra-arterial chemotherapy (SSIAC) for oral cancer can deliver a higher concentration of anticancer agent into a tumor-feeding artery than intravenous systemic chemotherapy. However, the agent distribution between the lingual artery and facial artery (FA) is not clear in SSIAC for patients with the linguofacial trunk. The agent distribution in the SSIAC method was investigated using computational fluid dynamics (CFD). Ten three-dimensional vessel models were created from CT images of two patients with oral cancer (patients A and B) with the linguofacial trunk. Catheter models were combined with vessel models to mimic intra-arterial infusion, and the agent flow was analyzed. In patient A models, the agent distribution varied depending on the catheter tip position in the linguofacial trunk, while all anticancer agents flowed into the FA only in patient B models. This study revealed that the behavior of the agent in the common trunk is determined by the blood flow field which depends on the topography of the vessels in each patient. Therefore, the catheter tip position should be changed according to the vessel topography to deliver anticancer agents into the tumor-feeding artery. Moreover, CFD can be a useful method to predict the agent flow for each patient before SSIAC.

中文翻译：

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口腔癌超选择性动脉内化疗的计算流体动力学研究：舌面部干道中抗癌剂的流动模拟

与静脉内全身化疗相比，用于口腔癌的超选择性动脉内化疗（SSIAC）可以将更高浓度的抗癌剂送入肿瘤喂养动脉。但是，对于舌面部干的患者，SSIAC中舌动脉和面动脉（FA）之间的药剂分布尚不清楚。使用计算流体动力学（CFD）研究了SSIAC方法中的代理分布。从两名患有舌面部干的口腔癌患者（患者A和B）的CT图像中创建了十个三维血管模型。将导管模型与血管模型相结合以模拟动脉内输注，并分析药物流。在A型患者模型中，药剂的分布随舌面部躯干中导管尖端的位置而变化，而所有抗癌药仅在B型患者模型中才流入FA。这项研究表明，药剂在总干线中的行为由血流场决定，血流场取决于每位患者的血管地形。因此，应根据血管的地形改变导管尖端的位置，以将抗癌药输送到肿瘤输送动脉中。此外，CFD可以是预测SSIAC之前每位患者的药物流量的有用方法。