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Silica Mesoporous Structures: Effective Nanocarriers in Drug Delivery and Nanocatalysts
Applied Sciences ( IF 2.838 ) Pub Date : 2020-10-26 , DOI: 10.3390/app10217533
Masoud Mirzaei , Malihe Babaei Zarch , Mahdieh Darroudi , Khalilollah Sayyadi , Seyed Tahmoures Keshavarz , Jalil Sayyadi , Azadeh Fallah , Hajar Maleki

The application of silica mesoporous structures in drug delivery and the removal of pollutants and organic compounds through catalytic reactions is increasing due to their unique characteristics, including high loading capacities, tunable pores, large surface areas, sustainability, and so on. This review focuses on very well-studied class of different construction mesoporous silica nano(particles), such as MCM-41, SBA-15, and SBA-16. We discuss the essential parameters involved in the synthesis of these materials with providing a diverse set of examples. In addition, the recent advances in silica mesoporous structures for drug delivery and catalytic applications are presented to fill the existing gap in the literature with providing some promising examples on this topic for the scientists in both industry and academia active in the field. Regarding the catalytic applications, mesoporous silica particles have shown some promises to remove the organic pollutants and to synthesize final products with high yields due to the ease with which their surfaces can be modified with various ligands to create appropriate interactions with target molecules. In the drug delivery process, as nanocarriers, they have also shown very good performance thanks to the easy surface functionalization but also adjustability of their porosities to providing in-vivo and in-vitro cargo delivery at the target site with appropriate rate.

中文翻译:

二氧化硅介孔结构:药物传递和纳米催化剂中的有效纳米载体。

二氧化硅介孔结构在药物输送以及通过催化反应去除污染物和有机化合物方面的应用由于其独特的特性而不断增加,这些特性包括高载量,可调节的孔,较大的表面积,可持续性等。这篇综述着重研究了种类非常丰富的不同结构的介孔二氧化硅纳米粒子,例如MCM-41,SBA-15和SBA-16。我们提供了一系列示例,讨论了这些材料合成中涉及的基本参数。另外,提出了用于药物递送和催化应用的二氧化硅介孔结构的最新进展,以填补文献中的现有空白,并为活跃于该领域的工业界和学术界的科学家提供了关于该主题的一些有希望的例子。关于催化应用,中孔二氧化硅颗粒显示出一些有望除去有机污染物并以高收率合成最终产物的方法,这是因为它们的表面可以容易地被各种配体修饰以与目标分子产生适当的相互作用。在药物输送过程中,作为纳米载体,它们还具有出色的性能,这要归功于其易于进行的表面功能化以及其孔隙率的可调节性,从而可以以适当的速率在目标部位提供体内和体外货物输送。介孔二氧化硅颗粒显示出一些有望去除有机污染物并以高收率合成最终产物的方法,这是因为其表面易于被各种配体修饰以与目标分子产生适当的相互作用。在药物输送过程中,作为纳米载体,它们还具有出色的性能,这要归功于其易于进行的表面功能化以及其孔隙率的可调节性,从而可以以适当的速率在目标部位提供体内和体外货物输送。介孔二氧化硅颗粒显示出一些有望去除有机污染物并以高收率合成最终产物的方法,这是因为其表面易于被各种配体修饰以与目标分子产生适当的相互作用。在药物输送过程中,作为纳米载体,它们还具有出色的性能,这要归功于其易于进行的表面功能化以及其孔隙率的可调节性,从而可以以适当的速率在目标部位提供体内和体外货物输送。
更新日期:2020-10-28
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