Numerous prescription drugs’ labeling contains pharmacogenomic (PGx) information to aid health providers and patients in the safe and effective use of drugs. However, clinical studies for such PGx biomarkers and related drug doses are generally not conducted in diverse ethnic populations. Thus, it is urgently important to incorporate PGx information with genetic characteristics of racial and ethnic minority populations and utilize it to promote minority health. In this project a bioinformatics approach was developed to enhance the collection of PGx information related to ethnic minorities to pave the way toward understanding the population-wide utility of PGx information. To address this challenge, we first gathered PGx information from drug labels. Second, we extracted data on the allele frequency information of genetic variants in ethnic minority groups from public resources. Then, we collected published research articles on PGx biomarkers and related drugs for reference. Finally, the data were integrated and formatted to build a new PGx database containing information on known drugs and biomarkers for ethnic minority groups. This database provides scientific information needed to evaluate available PGx information to enhance drug dose selection and drug safety for ethnic minority populations.

中文翻译：

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将有关药物安全性和有效性的药物基因组学信息与少数民族人口联系起来

许多处方药的标签均包含药物基因组学（PGx）信息，以帮助健康提供者和患者安全有效地使用药物。但是，通常不会在不同种族的人群中进行此类PGx生物标记物和相关药物剂量的临床研究。因此，将具有种族和少数民族人口遗传特征的PGx信息纳入并利用其促进少数民族健康迫在眉睫。在该项目中，开发了一种生物信息学方法来增强与少数民族相关的PGx信息的收集，从而为理解PGx信息在整个人群中的应用铺平道路。为了应对这一挑战，我们首先从药品标签中收集了PGx信息。第二，我们从公共资源中提取了少数民族群体遗传变异的等位基因频率信息。然后，我们收集了有关PGx生物标志物和相关药物的已发表研究文章，以供参考。最后，对数据进行整合和格式化，以建立一个新的PGx数据库，其中包含有关少数民族群体的已知药物和生物标记物的信息。该数据库提供了评估可用的PGx信息以增强少数族裔人群的药物剂量选择和药物安全性所需的科学信息。