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Dual-Emissive Fluorescent Sensor Based on Functionalized Quantum Dots for the Simultaneous Determination of Nitric Oxide and Hydrogen Sulfide
ACS Biomaterials Science & Engineering ( IF 5.8 ) Pub Date : 2020-10-27 , DOI: 10.1021/acsbiomaterials.0c00842
Guanhong Xu 1, 2 , Fangdi Wei 1, 2 , Yao Cen 1, 2 , Xia Cheng 1, 2 , Qin Hu 1, 2
Affiliation  

A simple, direct fluorescent sensor was developed to simultaneously determine nitric oxide and hydrogen sulfide based on 4-(((3-aminonaphthalen-2-yl)amino)methyl)benzoic acid (DAN-1)-functionalized CdTe/CdS/ZnS quantum dots (QDs@DAN-1). In this sensor, DAN-1 could specifically recognize nitric oxide and yield highly fluorescent naphtho triazole (DAN-1-T). Meanwhile, the fluorescence intensity of the QDs could be quenched by hydrogen sulfide. The QDs and DAN-1-T could be simultaneously excited at 365 nm, and their maximum emission wavelengths were 635 and 440 nm, respectively. Nitric oxide and hydrogen sulfide were simultaneously determined by monitoring two different fluorescence signals. The limits of determination for nitric oxide and hydrogen sulfide were 0.051 and 0.13 μM, respectively. The QDs@DAN-1 sensor was also applied to determine nitric oxide and hydrogen sulfide in human plasma. This sensor may provide a new strategy for investigating the relationship between nitric oxide and hydrogen sulfide and elucidating their roles in related physiological and pathophysiological processes at the same time.

中文翻译:

基于功能量子点的双发射荧光传感器同时测定一氧化氮和硫化氢

开发了一种简单的直接荧光传感器,用于基于4-(((3-氨基萘-2-基)氨基)甲基)苯甲酸(DAN-1)-官能化的CdTe / CdS / ZnS量子同时测定一氧化氮和硫化氢点(QDs @ DAN-1)。在这种传感器中,DAN-1可以特异性识别一氧化氮并产生高荧光的萘三唑(DAN-1-T)。同时,量子点的荧光强度可以被硫化氢猝灭。QD和DAN-1-T可以在365 nm处同时激发,其最大发射波长分别为635 nm和440 nm。通过监测两个不同的荧光信号同时测定一氧化氮和硫化氢。一氧化氮和硫化氢的测定极限分别为0.051和0.13μM。QDs @ DAN-1传感器也用于测定人体血浆中的一氧化氮和硫化氢。该传感器可能为研究一氧化氮和硫化氢之间的关系并同时阐明其在相关生理和病理生理过程中的作用提供了新的策略。
更新日期:2020-10-27
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