Diabetes mellitus induces skeletal muscle dysfunction, such as decreased metabolic activity and capillarization. This study aimed to investigate the effects of aerobic low intensity exercise training on metabolic oxidative capacity and capillarization in skeletal muscle of non-obese diabetic rats. Eleven to twenty-five week-old male non-obese Spontaneous Diabetic Torii (SDT) rats (n = 11) and age-matched healthy male Sprague-Dawley SD rats (n = 11) were randomly assigned to either exercise or sedentary groups. The exercise training was performed on a low-speed motorized treadmill (15 m min⁻¹) for 60 min per session, 5 sessions per week for 14 weeks in exercised groups. Sedentary SDT rats resulted in hyperglycemia, reduction of metabolic oxidative enzyme, and low percentage of oxidative fibers in the skeletal muscles. The low-intensity exercise training inhibited the growth-related increase in glucose level, and increased the muscle oxidative enzyme in exercised SDT rats compared with sedentary SDT rats. In addition, the exercise program prevented capillary regression in the skeletal muscle of diabetic rats. These results suggest that low-intensity exercise training may be an effective treatment to counter the detrimental effects of type 2 diabetes mellitus on the oxidative capacity and the capillary network of skeletal muscles.

糖尿病会引起骨骼肌功能障碍，例如代谢活动降低和毛细血管化。本研究旨在探讨有氧低强度运动训练对非肥胖糖尿病大鼠骨骼肌代谢氧化能力和毛细血管化的影响。十一至二十五周大的雄性非肥胖自发性糖尿病鸟居 (SDT) 大鼠 ( n = 11) 和年龄匹配的健康雄性 Sprague-Dawley SD 大鼠 ( n = 11) 被随机分配到运动组或久坐组。运动训练在低速电动跑步机上进行（15 m min ^-1) 每次训练 60 分钟，每周 5 次训练，共 14 周。久坐的 SDT 大鼠导致高血糖、代谢氧化酶减少和骨骼肌中氧化纤维的百分比低。与久坐的 SDT 大鼠相比，低强度运动训练抑制了与生长相关的葡萄糖水平升高，并增加了运动 SDT 大鼠的肌肉氧化酶。此外，锻炼计划可防止糖尿病大鼠骨骼肌的毛细血管退化。这些结果表明，低强度运动训练可能是对抗 2 型糖尿病对氧化能力和骨骼肌毛细血管网络的不利影响的有效治疗方法。