Hydrophilic interaction chromatography (HILIC) has attractive attention for the separation of water-soluble compounds via HPLC. There are, however, few studies on the pretreatment of the HILIC-type solid-phase extraction (SPE) due to the difficulty of obtaining the HILIC-type sorbent. Therefore, the development of HILIC-type sorbents for SPE is essential. In this study, four different hydrophilic copolymers, namely diallylamine–maleic acid copolymer (DAM), diallylamine–acrylamide copolymer (DAA), allylamine–maleic acid copolymer (MAM), and partly methylcarbonylated allylamine acetate copolymer (MAC), were immobilized on glycidyl methacrylate (GMA)-base resin, and their adsorptive properties were evaluated. The results of the physical and adsorptive properties indicated that a balance between the water content of the water-enriched layer on sorbent and the amount of hydrophilic copolymer immobilized on the GMA-base resin was vital for the adsorption in HILIC-type sorbent for SPE.

亲水相互作用色谱法（HILIC）对于通过HPLC。然而，由于难以获得HILIC型吸附剂，因此关于HILIC型固相萃取（SPE）的预处理的研究很少。因此，开发用于SPE的HILIC型吸附剂至关重要。在这项研究中，四种不同的亲水共聚物，即二烯丙基胺-马来酸共聚物（DAM），二烯丙基胺-丙烯酰胺共聚物（DAA），烯丙胺-马来酸共聚物（MAM）和部分甲基羰基化烯丙乙酸酯共聚物（MAC）被固定在缩水甘油基上评估了甲基丙烯酸酯（GMA）基树脂的吸附性能。