Two new compounds classified as one new lumazine peptide, penilumamide K (1) and one new sesquiterpene (2), were obtained from the deep-sea derived fungus Aspergillus sp. SCSIO 41029, together with eleven known compounds (3−13). The structures of 1−13 including absolute configurations were determined by detailed NMR spectroscopy, HR-ESI-MS, chemical derivatization, and optical rotation data. Among them, compound 1 represents the first lumazine peptide reported from deep-sea derived fungus. The bioactive assay exhibited that compounds 1, 3, 4, 5, 7 and 10 had significant potency against α-glucosidase with IC₅₀ values ranging from 18.61 to 109.06 μΜ. In addition, compounds 4 and 9 showed strong antibacterial activity against Staphylococcus aureus with MIC values of 0.78 and 6.25 μg ml⁻¹, respectively.

从深海来源的真菌曲霉属中获得了两种新化合物，即一种新的 lumazine 肽，penilumamide K ( 1 ) 和一种新的倍半萜 ( 2 ) 。SCSIO 41029，连同十一种已知化合物 ( 3 - 13 )。1 - 13的结构包括绝对构型是通过详细的 NMR 光谱、HR-ESI-MS、化学衍生化和旋光数据确定的。其中，化合物1代表了第一个从深海来源真菌报道的lumazine肽。生物活性测定表明，化合物1、3、4、5，7和10具有针对显著效力α与IC葡糖苷酶_50个值范围从18.61到109.06μΜ。此外，化合物4和9对金黄色葡萄球菌显示出很强的抗菌活性，MIC值分别为0.78和6.25 μg ml ^-1。