A contemporary synthesis of polymeric nanocarriers based on drug delivery systems was employed using a water in oil in water (W₁/O/W₂) double emulsion process to develop nicardipine hydrochloride‐loaded carboxymethyl cellulose/poly(D,L‐lactic‐co‐glycolic acid) (NCH‐CMC/PLGA) nanocarriers. The optimal synthesis of the nanocarriers was studied, including polymer amount, cross‐linker concentration, and emulsifier concentration. The synthesized nanocarriers were smaller than ∼169 nm and showed a drug encapsulation of more than 80% and a yield of 51% to 73%. The NCH‐CMC/PLGA nanocarriers presented good stability in aqueous dispersion for 10 days. Controlled drug release from the nanocarriers was slow and continuous for up to 16 days. The nanocarriers protected the drug against degradation and maintained therapeutic drug concentrations. In addition, the transport of drug release was studied via five conventional mathematical modelings such as Zero‐order model, First‐order model, Hixson‐Crowell model, Higuchi model, and Korsmeyer‐Peppas model. The Korsmeyer‐Peppas model was fitted to achieve mathematical modeling for the optimized formulation of nanocarriers. Moreover, significant cytocompatibility was observed at all tested doses of NCH‐CMC/PLGA nanocarriers. The NCH‐CMC/PLGA nanocarriers could be an effective drug delivery agent for calcium channel blockers.

中文翻译：

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盐酸尼卡地平负载羧甲基纤维素/聚（D，L-乳酸-乙醇酸）纳米载体的药物动力学

使用水包油型水（W ₁ / O / W ₂）双乳化工艺开发载有盐酸尼卡地平的羧甲基纤维素/聚（D，L-乳酸-乙醇酸）（NCH-CMC / PLGA）纳米载体。研究了纳米载体的最佳合成方法，包括聚合物量，交联剂浓度和乳化剂浓度。合成的纳米载体小于〜169 nm，显示出超过80％的药物包封率和51％至73％的产率。NCH-CMC / PLGA纳米载体在水分散液中可保持10天的良好稳定性。从纳米载体控制的药物释放缓慢且连续长达16天。纳米载体保护药物免于降解并保持治疗药物浓度。此外，还通过五个常规数学模型（如​​零阶模型，一阶模型，Hixson-Crowell模型，Higuchi模型和Korsmeyer-Peppas模型。拟合Korsmeyer-Peppas模型以实现数学模型，以优化纳米载体的配方。此外，在所有测试剂量的NCH-CMC / PLGA纳米载体上均观察到了显着的细胞相容性。NCH-CMC / PLGA纳米载体可能是钙通道阻滞剂的有效药物递送剂。