当前位置: X-MOL 学术Future J. Pharm. Sci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Possible neuropharmacological effects of Adenia trilobata (Roxb.) in the Swiss albino mice model
Future Journal of Pharmaceutical Sciences Pub Date : 2020-10-22 , DOI: 10.1186/s43094-020-00102-5
Md. Arfin Ibn Aziz , Niloy Barua , Abu Montakim Tareq , Najmul Alam , Ranak Jahan Prova , Miskatun Nur Mamun , Mohammed Aktar Sayeed , Md. Ashraf Uddin Chowdhury , Talha Bin Emran

Known colloquially as akandaphal in Bangladesh, Adenia trilobata has some traditional uses. Its leaves and stems are extracted with pure methanol (MEATL, MEATS) and fractioned by n-hexane (NFATL, NFATS). The in vivo anxiolytic activity was evaluated by elevated plus maze (EPM) testing and hole-board test (HBT), whilst the locomotor activity was examined using the open-field test (OFT) and hole-cross test (HCT) and the antidepressant activity was assessed with the forced swimming test (FST) and the tail suspension test (TST). Regarding the anxiolytic activity, the 400-mg/kg doses of MEATL, NFATL, MEATS and NFATS exhibited maximum percentages of entry into the open arm of 33.85%, 32.23%, 30.06% and 41.84%, respectively, compare with the diazepam (69.33%). During HBT, MEATL (400 mg/kg) and NFATL (400 mg/kg) demonstrated 51.67 ± 0.88 and 57.67 ± 3.18 instances of head-dipping relative to diazepam (64.33 ± 3.16), whilst the locomotor activity showed a dose-dependent reduction in square movements and number of hole crossings. During FST and TST, the NFATL (400 mg/kg) exhibited rates of 43.32% and 57.71% time spent immobile, whilst fluoxetine experienced rates of 54.79% and 55.74%. Adenia trilobata could be a potential component for the treatment of neuropharmacological defects. Further study is required.

中文翻译:

瑞士白化病小鼠模型中三叶草(Roxb。)的可能的神经药理作用

Adenia trilobata在孟加拉语中被俗称为akandaphal,它具有一些传统用途。其叶和茎用纯甲醇(MEATL,MEATS)提取,然后用正己烷(NFATL,NFATS)分离。体内抗焦虑活性通过高架迷宫(EPM)测试和孔板测试(HBT)进行评估,而运动能力则通过开放视野测试(OFT)和孔交叉测试(HCT)和抗抑郁药进行检查通过强制游泳测试(FST)和尾部悬吊测试(TST)评估活动能力。在抗焦虑活性方面,与地西epa相比,400 mg / kg剂量的MEATL,NFATL,MEATS和NFATS进入开放臂的最大百分比分别为33.85%,32.23%,30.06%和41.84%。 %)。在HBT期间,MEATL(400 mg / kg)和NFATL(400 mg / kg)分别为51.67±0.88和57.67±3。相对于地西epa,有18次浸头事件(64.33±3.16),而自发活动显示出正方形移动和交叉孔数的剂量依赖性降低。在FST和TST期间,NFATL(400 mg / kg)的固定停留时间为43.32%和57.71%,而氟西汀的发生率为54.79%和55.74%。三角叶腺可能是治疗神经药理缺陷的潜在成分。需要进一步研究。三角叶腺可能是治疗神经药理缺陷的潜在成分。需要进一步研究。三角叶腺可能是治疗神经药理缺陷的潜在成分。需要进一步研究。
更新日期:2020-10-27
down
wechat
bug