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A nineteen-year report of serotype and antimicrobial susceptibility of enteric non-typhoidal Salmonella from humans in Southern India: changing facades of taxonomy and resistance trend
Gut Pathogens ( IF 4.2 ) Pub Date : 2020-10-23 , DOI: 10.1186/s13099-020-00388-z
Jobin John Jacob 1 , Dhanalakshmi Solaimalai 1 , Dhiviya Prabaa Muthuirulandi Sethuvel 1 , Tanya Rachel 1 , Praveena Jeslin 1 , Shalini Anandan 1 , Balaji Veeraraghavan 1
Affiliation  

The steady increase in the proportion of Non-typhoidal Salmonella (NTS) infections in humans represents a major health problem worldwide. The current study investigated the serovar distribution and antimicrobial susceptibility trends of NTS isolated from faecal samples during the period 2000–2018. Faecal specimens of patients were cultured according to standard lab protocol. The isolates were serotyped and antimicrobial susceptibility testing (AST) were performed according to CLSI guidelines. A total of 1436 NTS isolates were obtained from faeces samples mostly comprising of S. Typhimurium (27.3%), S. Weltevreden (13%), S. Bareilly (11%), S. Newport (4.2%), S. Cholerasuis (4%), S. Infantis (3.4%), and S. Enteritidis (2.4%). Resistance to nalidixic acid (26%) was most common among the tested NTS, followed by ampicillin (18.5%), cotrimoxazole (13.5%), ciprofloxacin (12%), ceftriaxone (6.3%) and chloramphenicol (3.6%). Multidrug resistance was observed in 5% of NTS isolates with the highest rate (10.52%) in 2014. The incidence of NTS infection was maximum in children < 5 years of age with an average 19.3% of the total affected patients during the time period. Based on this study, the faecal NTS isolates have high resistance rates against first line antimicrobial agents except chloramphenicol. The gradual but consistent increase in resistance to fluoroquinolones, third generation cephalosporins and macrolide may restrict future treatment options. Hence periodic monitoring of NTS infections, serotype distribution and antimicrobial resistance trend is recommended.

中文翻译:

印度南部人类肠道非伤寒沙门氏菌的血清型和抗菌药物敏感性十九年报告:分类学和耐药趋势的变化

人类非伤寒沙门氏菌 (NTS) 感染比例的稳步增加是世界范围内的一个主要健康问题。本研究调查了2000年至2018年期间从粪便样本中分离出的NTS的血清型分布和抗菌药物敏感性趋势。根据标准实验室方案培养患者的粪便标本。根据 CLSI 指南对分离株进行血清分型并进行抗菌药物敏感性测试 (AST)。从粪便样本中总共获得了 1436 个 NTS 分离株,主要包括鼠伤寒沙门氏菌 (27.3%)、韦尔特夫雷登沙门氏菌 (13%)、巴雷利沙门氏菌 (11%)、纽波特沙门氏菌 (4.2%)、猪霍乱沙门氏菌 ( 4%)、婴儿沙门氏菌(3.4%)和肠炎沙门氏菌(2.4%)。在测试的 NTS 中,对萘啶酸 (26%) 的耐药性最常见,其次是氨苄西林 (18.5%)、复方新诺明 (13.5%)、环丙沙星 (12%)、头孢曲松 (6.3%) 和氯霉素 (3.6%)。5%的NTS分离株出现多重耐药,2014年出现最高比例(10.52%)。NTS感染的发生率在<5岁儿童中最高,平均占该时期受影响患者总数的19.3%。根据这项研究,粪便 NTS 分离株对除氯霉素以外的一线抗菌药物具有较高的耐药率。对氟喹诺酮类、第三代头孢菌素和大环内酯类药物的耐药性逐渐但持续增加可能会限制未来的治疗选择。因此,建议定期监测 NTS 感染、血清型分布和抗菌药物耐药性趋势。
更新日期:2020-10-26
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