Lung ultrasound (LUS) is a practical tool for lung diagnosis when computer tomography (CT) is not available. Recent findings suggest that LUS diagnosis is highly advantageous because of its mobility and correlation with radiological findings for viral pneumonia. Simple models for both educational evaluation and technical evaluation are needed. Therefore, this work investigates the usability of a large animal model under aspects of LUS features of viral pneumonia using saline one lung flooding. Six pigs were intubated with a double-lumen tube, and the left lung was instilled with saline. During the instillation of up to 12.5 ml/kg, the sonographic features were assessed. All features present during viral pneumonia were found, such as B-lines, white lung syndrome, pleural thickening, and the formation of pleural consolidations. Sonographic findings correlate well with current LUS scores for COVID19. The scores of 1, 2, and 3 were dominantly present at 1–4-, 4–8-, and 8–12-ml/kg saline instillation, respectively. The noninfective animal model can be used for further investigation of the LUS features and can serve in education, by helping with the appropriate handling of LUS in clinical practice during management of viral pneumonia.

中文翻译：

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体内 使用大型动物模型评估模仿病毒性肺炎的肺部超声特征

当无法使用计算机断层扫描（CT）时，肺部超声（LUS）是诊断肺部的实用工具。最近的发现表明LUS诊断具有高度的优势，因为它的活动性和与病毒性肺炎的放射学发现相关。需要用于教育评估和技术评估的简单模型。因此，这项工作使用盐水一次肺冲洗研究了病毒性肺炎的LUS特征下大型动物模型的可用性。用双腔管向六只猪插管，向左肺灌注生理盐水。在滴注高达12.5 ml / kg的过程中，评估了超声特征。发现病毒性肺炎期间存在的所有特征，例如B线，白肺综合症，胸膜增厚和胸膜固结的形成。超声检查结果与当前COVID19的LUS评分密切相关。分别以1–4、4–8–和8–12-ml / kg生理盐水滴注出现1、2和3评分。非感染性动物模型可通过在病毒性肺炎管理期间的临床实践中帮助适当处理LUS，从而用于LUS功能的进一步研究，并可用于教育。