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Transcriptional Diversity of Medium Spiny Neurons in the Primate Striatum
bioRxiv - Neuroscience Pub Date : 2021-03-24 , DOI: 10.1101/2020.10.25.354159
Jing He , Michael Kleyman , Jianjiao Chen , Aydin Alikaya , Kathryn M. Rothenhoefer , Bilge Esin Ozturk , Morgan Wirthlin , Kenneth Fish , Leah C. Byrne , Andreas R. Pfenning , William R. Stauffer

The striatum is the interface between dopamine reward signals and cortico-basal ganglia circuits that mediate diverse behavioral functions. Medium spiny neurons (MSNs) constitute the vast majority of striatal neurons and are traditionally classified as direct- or indirect-pathway neurons. However, that traditional model does not explain the anatomical and functional diversity of MSNs. Here, we defined molecularly distinct MSN types in the primate striatum, including (1) dorsal striatum MSN types associated with striosome and matrix compartments, (2) ventral striatum types associated with the nucleus accumbens shell and olfactory tubercle, and (3) an MSN-like type restricted to mu-opioid receptor rich islands in the ventral striatum. These results lay the foundation for achieving cell type-specific transgenesis in the primate striatum and provide a blueprint for investigating circuit-specific processing.

中文翻译:

灵长类纹状体中棘神经元的转录多样性

纹状体是多巴胺奖励信号和介导多种行为功能的皮质基底神经节回路之间的接口。中棘神经元(MSN)构成纹状体神经元的绝大部分,传统上被分类为直接或间接途径神经元。但是,该传统模型无法解释MSN的解剖和功能多样性。在这里,我们定义了灵长类纹状体中分子上不同的MSN类型,包括(1)与纹状体和基质区室相关的背侧纹状体MSN类型,(2)与伏隔核壳和嗅结节相关的腹侧纹状体类型,以及(3)MSN样类型仅限于腹侧纹状体中富含阿片类受体的岛。
更新日期:2021-03-25
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