The physiology of organisms depends on inter-organ communication in response to changes in the environment. Nuclear receptors are broadly expressed transcription factors that respond to circulating molecules to control many biological processes, including immunity, detoxification, and reproduction. Although the tissue-intrinsic roles of nuclear receptors in reproduction have been extensively studied, there is increasing evidence that nuclear receptor signaling in peripheral tissues can also influence oogenesis. We previously showed that the Drosophila nuclear receptor Seven up (Svp) is required in the adult fat body to regulate distinct steps of oogenesis; however, the relevant downstream targets of Svp remain unknown. Here, we took an RNA sequencing approach to identify candidate Svp targets specifically in the adult female fat body that might mediate this response. svp knockdown in the adult female fat body significantly downregulated immune genes involved in the first line of pathogen defense, suggesting a role for Svp in stimulating early immunity. In addition, we found that Svp transcriptionally regulates genes involved in each step of the xenobiotic detoxification response. Based on these findings, we propose a testable model in which Svp functions in the adult female fat body to stimulate early defense against pathogens and facilitate detoxification as part of its mechanisms to promote oogenesis.

生物体的生理机能依赖于响应环境变化的器官间通讯。核受体是广泛表达的转录因子，它们响应循环分子以控制许多生物过程，包括免疫、解毒和繁殖。尽管已经广泛研究了核受体在生殖中的组织内在作用，但越来越多的证据表明，外周组织中的核受体信号传导也可以影响卵子发生。我们之前表明，果蝇成人脂肪体需要核受体七上（Svp）来调节卵子发生的不同步骤；但是，Svp 的相关下游目标仍然未知。在这里，我们采用 RNA 测序方法来识别可能介导这种反应的成年女性脂肪体中的候选 Svp 目标。副总裁成年女性脂肪体的敲低显着下调了参与第一道病原体防御的免疫基因，这表明 Svp 在刺激早期免疫中的作用。此外，我们发现 Svp 转录调节参与外源性解毒反应每个步骤的基因。基于这些发现，我们提出了一个可测试的模型，其中 Svp 在成年女性脂肪体中发挥作用，以刺激对病原体的早期防御并促进解毒，作为其促进卵子发生机制的一部分。