Scientists have increasingly recognised that low methodological and analytical rigour combined with publish-or-perish incentives can make the published scientific literature unreliable. As a response to this, large-scale systematic replications of the literature have emerged as a way to assess the problem empirically. The Brazilian Reproducibility Initiative is one such effort, aimed at estimating the reproducibility of Brazilian biomedical research. Its goal is to perform multicentre replications of a quasi-random sample of at least 60 experiments from Brazilian articles published over a 20-year period, using a set of common laboratory methods. In this article, we describe the challenges of managing a multicentre project with collaborating teams across the country, as well as its successes and failures over the first two years. We end with a brief discussion of the Initiative’s current status and its possible future contributions after the project is concluded in 2021.

中文翻译：

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巴西可再生性计划开展了两年：对大规模复制巴西生物医学进行反思

科学家越来越认识到，方法论和分析上的严谨性与发布或毁灭性激励措施相结合会导致已发表的科学文献不可靠。作为对此的回应，出现了对文献进行大规模系统复制的方法，以此作为凭经验评估问题的方法。巴西可再生性倡议就是其中之一，旨在评估巴西生物医学研究的可重复性。它的目标是使用一组常见的实验室方法，对20年来发表的巴西文章进行的至少60个实验的准随机样本进行多中心复制。在本文中，我们描述了与全国各地的协作团队一起管理多中心项目的挑战，以及该项目在头两年的成败。