Biobased Spiroimides from Itaconic Acid and Formamides: Molecular Targets for a Novel Synthetic Application of Renewable Chemicals,Synthesis

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Biobased Spiroimides from Itaconic Acid and Formamides: Molecular Targets for a Novel Synthetic Application of Renewable Chemicals
Synthesis ( IF 2.6 ) Pub Date : 2020-10-20 , DOI: 10.1055/s-0040-1707318
Leandro Helgueira Andrade , Milene Macedo Hornink , Alice Uva Lopes

Abstract

Spiroimides exhibit a wide range of biological activities, such as anticonvulsant, antiarrhythmic, and antihyperglycemic activities. Herein, a novel synthetic application of renewable chemicals, itaconic acid and formamides, is described. Proper exploitation of the reactivity of itaconic acid and formamide allows for the development of an efficient synthetic approach for the production of several new biobased spiroimides, spiro[dihydroquinolin-2-one-succinimides] and spiro[indolin-2-one-glutarimides], in excellent overall yields (up to 98%).

Publication History

Received: 17 June 2020

Accepted after revision: 08 September 2020

Publication Date:
20 October 2020 (online)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

中文翻译：

从衣康酸和甲酰胺的生物基螺酰亚胺：可再生化学物质的新型合成应用的分子靶标

摘要

螺酰亚胺具有广泛的生物学活性，例如抗惊厥，抗心律不齐和抗高血糖活性。在此，描述了可再生化学物质，衣康酸和甲酰胺的新型合成应用。适当利用衣康酸和甲酰胺的反应性，可以开发出一种有效的合成方法，用于生产几种新型的生物基螺酰亚胺，螺[二氢喹啉-2-酮-琥珀酰亚胺]和螺[吲哚-2-酮-戊二酰亚胺]，总产量极高（高达98％）。