Highly efficient removal of bilirubin from blood by hemoperfusion for liver failure therapy remains a challenge in the clinical field due to the low adsorption capacity and slow adsorption kinetics of currently used bilirubin adsorbents (e.g., activated carbon and ion‐exchange resin). Recently, porous aromatic frameworks (PAFs) with high surface areas, tunable structures, and remarkable stability provide numerous possibilities to obtain satisfying adsorbents. Here, a cationic PAF with more mesopores, named iPAF‐6, is successfully constructed via a de novo synthetic strategy for bilirubin removal. The prepared iPAF‐6 exhibits a record‐high adsorption capacity of 1249 mg g⁻¹ and can adsorb bilirubin from 150 mg L⁻¹ to normal concentration in just 5 min. Moreover, iPAF‐6 shows a removal efficiency of 96% toward bilirubin in the presence of 50 g L⁻¹ bovine serum albumin. It is demonstrated that positively charged aromatic frameworks and large pore size make a significant contribution to its excellent adsorption ability. More notably, iPAF‐6/polyethersulfone composite fibers or beads are fabricated for practical hemoperfusion adsorption, which also show better removal performance than commercial adsorbents. This work can offer a new possibility for designing PAF‐based bilirubin adsorbents with an appealing application prospect.

中文翻译：

---

具有定制结合位点和孔径的多孔芳香框架作为去除胆红素的高性能血液灌流吸附剂

由于目前使用的胆红素吸附剂（例如活性炭和离子交换树脂）的吸附能力低且吸附动力学慢，通过血液灌流高效去除血液中的胆红素用于肝衰竭治疗仍然是临床领域的挑战。最近，具有高表面积、可调结构和卓越稳定性的多孔芳香骨架（PAF）为获得令人满意的吸附剂提供了多种可能性。在这里，通过从头合成策略成功构建了具有更多中孔的阳离子 PAF，称为 iPAF-6，用于去除胆红素。所制备的iPAF-6表现出创纪录的高吸附容量，达到1249 mg g ^-1，并且可以在短短5分钟内将胆红素从150 mg L ^-1吸附到正常浓度。^{此外，在50 g L -1}牛血清白蛋白存在下，iPAF-6对胆红素的去除效率为96% 。结果表明，带正电荷的芳香骨架和大孔径对其优异的吸附能力做出了重大贡献。更值得注意的是，iPAF-6/聚醚砜复合纤维或珠子是为实际血液灌流吸附而制造的，其也表现出比商业吸附剂更好的去除性能。这项工作为设计基于PAF的胆红素吸附剂提供了新的可能性，具有诱人的应用前景。