Mesoporous titanium peroxide TiO_x nanospheres with a high surface area are synthesized for the application of an advanced drug system. The mesoporous TiO_x nanospheres have a high specific surface area of 681.89 m²/g and suitable pore size (∼3 nm) that can effectively upload doxorubicin (DOX) and possesses a high drug storage capacity of 146.08%. They show a distinct ability to produce reactive oxygen species (ROS) in response to X-ray irradiation, which can effectively improve the radiotherapy in tumor treatment using the lung cancer cell line. The ROS generation of TiO_x is more than ten-fold higher than that of TiO₂. No apparent toxicity is found for the TiO_x material itself without X-ray irradiation. In vitro and in vivo experiments show that TiO_x/DOX nanodrugs significantly enhance cytotoxicity in response to X-ray irradiation. CCK8 assays display that the TiO_x/DOX nanodrug has higher cancer treatment efficiency in response to X-ray irradiation because of the synergistic effect of chemotherapy and generation of ROS. In the in vivo experiments using lung cancer tumor-bearing mice model, the tumor inhibition rate in the TiO_x/DOX + X-ray group increased by 90.4% compared to the untreated control group, showing a good synergistic chemo-radiotherapy effect in tumor treatment.

中文翻译：

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软X射线增强介孔过氧化钛中活性氧的生成及其在肿瘤协同治疗中的应用

合成了具有高表面积的介孔过氧化钛 TiO _{x纳米球，用于先进的药物系统。}介孔TiO _x^{纳米球具有681.89 m 2} /g的高比表面积和合适的孔径（~3 nm），可以有效地加载阿霉素（DOX），并具有146.08%的高药物储存容量。它们显示出响应 X 射线照射产生活性氧 (ROS) 的独特能力，这可以有效地改善使用肺癌细胞系治疗肿瘤的放射治疗。_{TiO x}的 ROS 生成量是 TiO ₂的十倍以上。_{TiO x}没有发现明显的毒性材料本身无需 X 射线照射。体外和体内实验表明，TiO _x /DOX 纳米药物显着增强了对 X 射线照射的细胞毒性。CCK8 分析表明，由于化疗和 ROS 产生的协同作用，TiO _x /DOX 纳米药物对 X 射线照射具有更高的癌症治疗效率。在使用肺癌荷瘤小鼠模型进行的体内实验中，TiO _x /DOX + X射线组与未治疗的对照组相比，肿瘤抑制率提高了90.4%，表现出良好的肿瘤协同放化疗效果。治疗。