Developments in mass spectrometry technologies have driven a widespread interest and expanded their use in cancer-related research and clinical applications. In this review, we highlight the developments in mass spectrometry methods and instrumentation applied to direct tissue analysis that have been tailored at enhancing performance in clinical research as well as facilitating translation and implementation of mass spectrometry in clinical settings, with a focus on cancer-related studies. Notable studies demonstrating the capabilities of direct mass spectrometry analysis in biomarker discovery, cancer diagnosis and prognosis, tissue analysis during oncologic surgeries, and other clinically relevant problems that have the potential to substantially advance cancer patient care are discussed. Key challenges that need to be addressed before routine clinical implementation including regulatory efforts are also discussed. Overall, the studies highlighted in this review demonstrate the transformative potential of mass spectrometry technologies to advance clinical research and care for cancer patients. © 2020 Wiley Periodicals, Inc. Mass Spec Rev

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在临床和手术中使用质谱技术来促进癌症患者的护理

质谱技术的发展引起了广泛的兴趣，并扩大了它们在癌症相关研究和临床应用中的应用。在这篇综述中，我们重点介绍了应用于直接组织分析的质谱方法和仪器的发展，这些方法和仪器专为提高临床研究的性能以及促进质谱在临床环境中的转化和实施而量身定制，重点是癌症相关学习。显着的研究证明了直接质谱分析在生物标志物发现、癌症诊断和预后、肿瘤手术期间的组织分析以及有可能显着推进癌症患者护理的其他临床相关问题方面的能力。还讨论了在常规临床实施之前需要解决的关键挑战，包括监管工作。总体而言，本综述中强调的研究证明了质谱技术在推进癌症患者的临床研究和护理方面的变革潜力。© 2020 Wiley Periodicals, Inc. 质谱修订版