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Loganetin and 5‐fluorouracil synergistically inhibit the carcinogenesis of gastric cancer cells via down‐regulation of the Wnt/β‐catenin pathway
Journal of Cellular and Molecular Medicine ( IF 5.3 ) Pub Date : 2020-10-24 , DOI: 10.1111/jcmm.15932
Huaixiang Zhou 1 , Xiaoge Hu 2 , Na Li 2 , Guangyan Li 3 , Xiaotian Sun 4 , Feimin Ge 2 , Jiahong Jiang 1, 2 , Jingchun Yao 3 , Dongsheng Huang 2 , Liu Yang 1, 2
Affiliation  

Although most gastrointestinal tumours are sensitive to 5‐fluorouracil (5FU), drug resistance is commonly occurred after 5FU therapy in gastric cancer (GC). Loganetin is the primary active compound in Cornus officinali. However, the synergetic effects of loganetin and 5FU on GC remain unknown. Here, we investigated the synergetic effects and the underlying mechanism of loganetin and 5FU on proliferation, stem‐like properties, migration, and invasion of GC both in vitro and in vivo. We found that loganetin alone inhibited the proliferation, stem‐like properties, migration and invasion of GC cells in vitro. Importantly, the loganetin remarkably enhanced the anti‐cancer effect of 5FU on GC cells and the Wnt/β‐catenin pathway might be involved in this process. Animal experiments further confirmed the synergistic effects of 5FU and loganetin on inhibiting cell growth and metastasis of GC. These results suggested that loganetin could synergistically increase the effect of 5FU against GC, which sheds light on effective combinational drug strategies for GC treatment.

中文翻译:

Loganetin和5-氟尿嘧啶通过下调Wnt/β-catenin通路协同抑制胃癌细胞的癌变

尽管大多数胃肠道肿瘤对 5-氟尿嘧啶 (5FU) 敏感,但在胃癌 (GC) 中 5FU 治疗后通常会出现耐药性。Loganetin 是山茱萸中的主要活性化合物. 然而,loganetin 和 5FU 对 GC 的协同作用仍然未知。在这里,我们研究了马钱素和 5FU 在体外和体内对 GC 的增殖、茎样特性、迁移和侵袭的协同作用及其潜在机制。我们发现,在体外,单用马钱素可抑制 GC 细胞的增殖、干细胞样特性、迁移和侵袭。重要的是,马钱素显着增强了 5FU 对 GC 细胞的抗癌作用,Wnt/β-catenin 通路可能参与了这一过程。动物实验进一步证实了5FU和马钱素对抑制GC细胞生长和转移的协同作用。这些结果表明,loganetin 可以协同增加 5FU 对 GC 的作用,这为 GC 治疗的有效联合药物策略提供了启示。
更新日期:2020-10-26
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