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Aggregation‐Induced Emission Luminogens for Mitochondria‐Targeted Cancer Therapy
ChemMedChem ( IF 3.4 ) Pub Date : 2020-10-22 , DOI: 10.1002/cmdc.202000632
Yanyan Huang 1, 2 , Guanxin Zhang 1, 2 , Rui Zhao 1, 2 , Deqing Zhang 1, 2
Affiliation  

The importance of mitochondria in tumorigenesis makes these organelles an ideal target for cancer therapy. In recent years, luminogens with the aggregation‐induced emission (AIE) effect have been developed for mitochondrial targeting and cancer treatment. The induction of mitochondrial dysfunction can be an effective pathway of chemotherapy, photodynamic therapy, and combination therapy against cancer. This review focuses on recent progress in the field of AIE luminogens (AIEgens) for cancer theranostics based on mitochondrial targeting and dysfunction. AIEgens for cancer treatment, including chemotherapy, photodynamic therapy, and combination therapy, are summarized herein. Molecular design efforts toward mitochondrial targeting and mitochondria‐damaging mechanisms are also discussed. Finally, we discuss the challenges and future directions of development for AIEgens in mitochondria‐targeted cancer treatment.

中文翻译:

用于线粒体靶向癌症治疗的聚集诱导发射发光原

线粒体在肿瘤发生中的重要性使这些细胞器成为癌症治疗的理想靶点。近年来,具有聚集诱导发射(AIE)效应的发光体已被开发用于线粒体靶向和癌症治疗。线粒体功能障碍的诱导可能是化疗、光动力疗法和抗癌联合疗法的有效途径。本综述重点介绍基于线粒体靶向和功能障碍的癌症治疗诊断学 AIE 发光原 (AIEgens) 领域的最新进展。本文总结了用于癌症治疗的 AIEgen,包括化学疗法、光动力疗法和联合疗法。还讨论了针对线粒体靶向和线粒体损伤机制的分子设计工作。最后,
更新日期:2020-12-03
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