There has been growing scientific evidence in recent years that bipolar disorder (BD) is associated with alterations in the kynurenine (KYN) pathway. However, many of these studies have been limited by their focus on adults. Thus, this preliminary study investigated differences in the peripheral levels of KYN metabolites in children and adolescents with BD, unaffected offspring of parents with BD, and healthy controls (HCs).

中文翻译：

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患有双相情感障碍的儿童和青少年以及双相情感障碍父母未受影响的后代血浆犬尿氨酸途径代谢物的变化：初步研究

近年来，越来越多的科学证据表明双相情感障碍 (BD) 与犬尿氨酸 (KYN) 通路的改变有关。然而，其中许多研究因其对成人的关注而受到限制。因此，这项初步研究调查了患有 BD 的儿童和青少年、患有 BD 的父母未受影响的后代以及健康对照 (HC) 中 KYN 代谢物的外周水平差异。