One of the most widely used methods to detect an acute viral infection in clinical specimens is diagnostic real-time polymerase chain reaction. However, because of the COVID-19 pandemic, mass-spectrometry-based proteomics is currently being discussed as a potential diagnostic method for viral infections. Because proteomics is not yet applied in routine virus diagnostics, here we discuss its potential to detect viral infections. Apart from theoretical considerations, the current status and technical limitations are considered. Finally, the challenges that have to be overcome to establish proteomics in routine virus diagnostics are highlighted.

中文翻译：

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临床样本中病毒检测的蛋白质组学展望

检测临床样本中急性病毒感染最广泛使用的方法之一是诊断性实时聚合酶链反应。然而，由于 COVID-19 大流行，目前正在讨论基于质谱的蛋白质组学作为病毒感染的潜在诊断方法。由于蛋白质组学尚未应用于常规病毒诊断，因此我们在此讨论其检测病毒感染的潜力。除了理论考虑之外，还考虑了现状和技术限制。最后，强调了在常规病毒诊断中建立蛋白质组学必须克服的挑战。