Diabetic foot ulcers (DFU) remain a very considerable health care burden, and their treatment is difficult. Hydrogel‐based wound dressings are appealing to provide an optimal environment for wound repair. However, the currently available hydrogel dressings still need surgical or mechanical debridement from the wound, causing reinjury of the newly formed tissues, wound infection, delayed healing time, and personal suffering. Additionally, to meet people's increasing demand, hydrogel wound dressings with improved performance and multifunctionality are urgently required. Here, a new multifunctional supramolecular hydrogel for on‐demand dissolvable diabetic foot wound dressings is designed and constructed. Based on multihydrogen bonds between hydrophilic polymers, the resultant supramolecular hydrogels present controlled and excellent properties, such as good transparency, antibacterial ability, conductive, and self‐healing properties. Thus, the supramolecular hydrogels improve the new tissue formation and provide a significant therapeutic effect on DFU by inducing angiogenesis, enhancing collagen deposition, preventing bacterial infection, and controlling wound infection. Remarkably, the resultant hydrogels also exhibit stimuli‐responsive ability, which renders its capability to be dissolved on‐demand, allowing for a facile DFU dressing removal. This multifunctional supramolecular hydrogel may provide a novel concept in the design of on‐demand dissolvable wound dressings.

中文翻译：

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具有刺激响应特性的透明导电超分子水凝胶，可按需溶解于糖尿病足伤口敷料

糖尿病足溃疡（DFU）仍然是非常可观的医疗保健负担，并且治疗困难。基于水凝胶的伤口敷料吸引人，为伤口修复提供了最佳环境。然而，当前可用的水凝胶敷料仍需要从伤口进行外科或机械清创术，导致新形成的组织再损伤，伤口感染，延迟的愈合时间和个人痛苦。另外，为了满足人们日益增长的需求，迫切需要具有改善的性能和多功能性的水凝胶伤口敷料。在这里，设计并构建了一种新型的按需溶解糖尿病足伤口敷料的多功能超分子水凝胶。基于亲水聚合物之间的多氢键，所得超分子水凝胶具有可控的优异性能，例如良好的透明度，抗菌能力，导电性和自我修复特性。因此，超分子水凝胶通过诱导血管生成，增强胶原蛋白沉积，防止细菌感染和控制伤口感染，改善了新组织的形成，并为DFU提供了显着的治疗作用。值得注意的是，所得水凝胶还具有刺激反应能力，使其能够按需溶解，从而可以轻松去除DFU敷料。这种多功能的超分子水凝胶可为按需溶解伤口敷料的设计提供一个新颖的概念。超分子水凝胶通过诱导血管生成，增强胶原蛋白沉积，防止细菌感染和控制伤口感染，改善了新组织的形成，并为DFU提供了显着的治疗作用。值得注意的是，所得水凝胶还具有刺激反应能力，使其能够按需溶解，从而可以轻松去除DFU敷料。这种多功能的超分子水凝胶可为按需溶解伤口敷料的设计提供一个新颖的概念。超分子水凝胶通过诱导血管生成，增强胶原蛋白沉积，防止细菌感染和控制伤口感染，改善了新组织的形成，并为DFU提供了显着的治疗作用。值得注意的是，所得水凝胶还具有刺激反应能力，使其能够按需溶解，从而可以轻松去除DFU敷料。这种多功能的超分子水凝胶可为按需溶解伤口敷料的设计提供一个新颖的概念。