Excess production of reactive oxygen species and the loss of antioxidant efficiency systems play an important role in the development of diabetes. Thus, using antioxidant compounds is an important strategy to reduce these complications. This study aimed to investigate the possible effect of camphor on the serum biochemical parameters and oxidative parameters in the pancreas, liver, and kidney tissues of alloxan‐induced diabetic rats. In this study, 40 male Wistar rats were divided into five groups, including normal group, diabetic group, the diabetic group treated with glibenclamide, the diabetic group treated with 30 mg/kg camphor, and the diabetic group receiving the camphor solvent. Intragastric administration of camphor and glibenclamide, as the control drug, to diabetic rats for 21 days lowered their blood glucose, total cholesterol, triglyceride, and LDL‐cholesterol, while the blood high‐density lipoprotein ‐cholesterol level was increased. In addition, our results indicated that treatment of diabetic rats with camphor increased the activity of glutathione peroxidase, catalase, and superoxide dismutase enzymes as well as reduced glutathione content in the liver, pancreas, and kidney tissues as compared to the diabetic rats. Based on our data, it can be concluded that camphor has a hypoglycemic activity, and this effect may be attributed, in part, to its antioxidant ability.

中文翻译：

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樟脑对四氧嘧啶致糖尿病大鼠肝，肾和胰腺组织抗氧化防御系统的调节

活性氧的过量生产和抗氧化剂效率体系的丧失在糖尿病的发展中起着重要作用。因此，使用抗氧化剂化合物是减少这些并发症的重要策略。本研究旨在探讨樟脑对四氧嘧啶致糖尿病大鼠胰腺，肝脏和肾脏组织中血清生化参数和氧化参数的影响。在本研究中，将40只雄性Wistar大鼠分为5组，分别为正常组，糖尿病组，格列本脲治疗的糖尿病组，30 mg / kg樟脑治疗的糖尿病组和接受樟脑溶剂的糖尿病组。给予樟脑和格列本脲作为对照药物在胃内给予糖尿病大鼠21天，可降低其血糖，总胆固醇，甘油三酸酯和低密度脂蛋白胆固醇，而血液中高密度脂蛋白胆固醇水平升高。另外，我们的结果表明，与糖尿病大鼠相比，用樟脑治疗糖尿病大鼠可增加谷胱甘肽过氧化物酶，过氧化氢酶和超氧化物歧化酶的活性，并减少肝脏，胰腺和肾脏组织中谷胱甘肽的含量。根据我们的数据，可以得出结论，樟脑具有降血糖活性，这种作用可能部分归因于其抗氧化能力。与糖尿病大鼠相比，肝脏，胰腺和肾脏组织中的超氧化物歧化酶和谷胱甘肽含量降低。根据我们的数据，可以得出结论，樟脑具有降血糖活性，这种作用可能部分归因于其抗氧化能力。与糖尿病大鼠相比，肝脏，胰腺和肾脏组织中的超氧化物歧化酶和谷胱甘肽含量降低。根据我们的数据，可以得出结论，樟脑具有降血糖活性，这种作用可能部分归因于其抗氧化能力。