Although Charles Frederic Gerhardt was the first to create acetylsalicylic acid in 1853, Felix Hoffman, a chemist working for Bayer, is credited with the synthesis as he acetylated acetylsalicylic acid in 1897. This became modern day aspirin we use widely for pain relief. In 1950 Lawrence Craven, a general practitioner first hypothesized that aspirin could be used preventatively for thrombotic events after making a connection between frequent hemorrhaging in those who chewed aspirin gum after tonsillectomy.

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是否应该对阿司匹林进行抑郁症的二级预防测试？‐评论

尽管查尔斯·弗雷德里克·格哈特（Charles Frederic Gerhardt）于1853年率先创建了乙酰水杨酸，但拜耳（Bayer）的化学家费利克斯·霍夫曼（Felix Hoffman）在1897年将乙酰水杨酸乙酰化后就被认为是合成的产物。这成为了现代的阿司匹林，我们广泛用于缓解疼痛。1950年，全科医生劳伦斯·克雷文（Lawrence Craven）首先假设，在扁桃体切除术后咀嚼阿司匹林口香糖者经常出血之间存在联系后，可以预防性地将阿司匹林用于血栓事件。