In recent years, solvent-less mechanochemical organic transformations using ball milling have come to the forefront of organic synthesis as cleaner and sustainable synthetic alternatives. Apart from the environmental benefits, mechanochemical approaches potentially enable access to novel chemical space that has reactivities and selectivities different from those of conventional solution-based reactions. In this review, we highlight important recent contributions to cross-coupling chemistry using ball milling, with particular emphasis on new synthetic strategies and concepts based on mechanochemical reaction environments that enable the rapid and selective construction of complex molecules.

近年来，使用球磨进行的无溶剂机械化学有机转化已成为有机合成的最前沿，作为清洁，可持续的合成替代品。除了对环境的好处外，机械化学方法还可能使人们能够进入具有与常规基于溶液的反应不同的反应性和选择性的新型化学空间。在这篇综述中，我们重点介绍了最近对使用球磨进行的交叉偶联化学的重要贡献，并特别强调了基于机械化学反应环境的新合成策略和概念，这些化学方法能够快速，选择性地构建复杂分子。