Prokaryote adaptive immunity (CRISPR-Cas systems) can be a threat to its carriers. We analyze the risks of autoimmune reactions related to adaptive immunity in prokaryotes by computational methods. We found important differences between bacteria and archaea with respect to autoimmunity potential. According to the results of our analysis, CRISPR-Cas systems in bacteria are more prone to self-targeting even though they possess fewer spacers per organism on average than archaea. The results of our study provide opportunities to use self-targeting in prokaryotes for biological and medical applications.

中文翻译：

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CRISPR-Cas系统自我靶向背景下的原核生物自身免疫

原核生物适应性免疫（CRISPR-Cas系统）可能对其携带者构成威胁。我们通过计算方法分析与原核生物适应性免疫相关的自身免疫反应的风险。我们发现细菌和古细菌在自身免疫潜力方面存在重要差异。根据我们的分析结果，细菌中的 CRISPR-Cas 系统更容易自我靶向，即使它们平均每个生物体比古细菌拥有更少的间隔物。我们的研究结果为在原核生物中使用自我靶向进行生物和医学应用提供了机会。