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Development of an immunogenomic landscape for the competing endogenous RNAs network of peri-implantitis
BMC Medical Genetics ( IF 2.023 ) Pub Date : 2020-10-20 , DOI: 10.1186/s12881-020-01145-4
Yang Li , Jina Zheng , Chanjuan Gong , Kengfu Lan , Yuqing Shen , Xiaojun Ding

Peri-implantitis is an inflammation that occurs around the implant, resulting in varying degrees of inflammatory damage to the soft and hard tissues. The characteristic criterion is the loss of the supporting bone in an inflammatory environment. However, the specific mechanisms and biomarkers involved in peri-implantitis remain to be further studied. Recently, competing endogenous RNAs (ceRNA) and immune microenvironment have been found to play a more important role in the inflammatory process. In our study, we analyzed the expression of immune related microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and message RNAs (mRNAs) in peri-implantitis by analyzing GSE33774 and GSE57631. In this study, we explored the expression profile data of immune-related lncRNAs, miRNAs and mRNAs, and constructed immune-related ceRNA network involved in the pathogenesis of peri-implantitis. In addition, the CIBERSORT was used to evaluate the content of immune cells in normal tissues and peri-implantitis to detect the immune microenvironment of peri-implantitis. In the analysis, 14 DElncRNAs, 16 DEmiRNAs, and 18 DEmRNAs were used to establish an immune related ceRNA network and the immune infiltration patterns associated with peri-implantitis was discovered. Through the mutual verification of the two datasets, we found that GSK3B and miR-1297 may have important significance in the immune microenvironment and pathogenesis of peri-implantitis and GSK3B was closely related to four types of immune cells, especially with the highest correlation with resting mast cells (P = 0.0003). Through immune-related ceRNA network, immune-related genes (IRGs) and immune cell infiltration can further comprehensively understand the pathogenesis of peri-implantitis, which built up an immunogenomic landscape with clinical significance for peri-implantitis.

中文翻译:

种植体周围炎的竞争性内源性RNA网络的免疫基因组学研究进展

种植体周围炎是发生在植入物周围的炎症,导致对软组织和硬组织的不同程度的炎症损害。特征性标准是炎性环境中支撑骨的丢失。然而,植入物周围炎的具体机制和生物标志物仍有待进一步研究。最近,已发现竞争性内源RNA(ceRNA)和免疫微环境在炎症过程中起着更重要的作用。在我们的研究中,我们通过分析GSE33774和GSE57631分析了免疫相关的microRNA(miRNA),长非编码RNA(lncRNA)和消息RNA(mRNA)在种植体周围炎中的表达。在这项研究中,我们探索了与免疫相关的lncRNA,miRNA和mRNA的表达谱数据,并构建了涉及种植体周围炎发病机制的与免疫相关的ceRNA网络。此外,CIBERSORT用于评估正常组织和种植体周围炎中免疫细胞的含量,以检测种植体周围炎的免疫微环境。在分析中,使用14个DElncRNA,16个DEmiRNA和18个DEmRNA建立了免疫相关的ceRNA网络,并发现了与种植体周围炎相关的免疫浸润模式。通过对这两个数据集的相互验证,我们发现GSK3B和miR-1297在免疫微环境中可能具有重要意义,并且植入物周围炎的发病机制与GSK3B与四种类型的免疫细胞密切相关,尤其与静息相关性最高。肥大细胞(P = 0.0003)。通过与免疫相关的ceRNA网络,
更新日期:2020-10-20
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