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Clinical Non-Motor Phenotyping of Black and Asian Minority Ethnic Compared to White Individuals with Parkinson’s Disease Living in the United Kingdom
Journal of Parkinson’s Disease ( IF 5.2 ) Pub Date : 2020-10-17 , DOI: 10.3233/jpd-202218
Anna Sauerbier 1, 2, 3 , Anette Schrag 4 , Richard Brown 2, 5 , Pablo Martinez-Martin 6 , Dag Aarsland 2, 7 , Nicola Mulholland 8 , Gill Vivian 8 , Haidar S Dafsari 3 , Alexandra Rizos 1 , Ben Corcoran 8 , Jozef Jarosz 9 , Loizos Siakallis 9 , K Ray Chaudhuri 1, 2
Affiliation  

Background:Ethnic phenotypic differences in Parkinson’s disease (PD) are important to understand the heterogeneity of PD and develop biomarkers and clinical trials. Objective:To investigate (i) whether there are non-motor symptoms (NMS)-and comorbidity-based phenotypic differences between Black, Asian and Minority Ethnic (BAME) and White PD patients and (ii) whether clinically available biomarkers may help differentiate and explain the diversity. Methods:This is a multicentre (four sites, London), real-life, cross-sectional study including PD patients of BAME or White ethnicity. The primary outcome was a detailed NMS assessment, additional measurements included disease and motor stage, comorbidity, sociodemographic parameters and brain MRI imaging. Results:271 PD patients (54 Asian, 71 Black, and 146 White) were included balanced for age, gender, and disease severity (HY). Black patients had a shorter disease duration compared to White and Asian populations. The SCOPA-Motor activities of daily living scores as well as the NMSS scores were significantly higher in both Black (total score and domain “miscellaneous”) and Asian (total score and domains “sleep/fatigue”, mood/apathy” and perception/hallucinations) than White individuals. Both BAME populations had higher prevalence of arterial hypertension, and the Black population had a higher prevalence of diabetes mellitus. Brain MRI revealed a greater severity of white matter changes in Black compared to the White and Asian cohorts. Conclusion:These findings suggest differences in phenotype of PD in BAME populations with greater burden of NMS and motor disability and a higher rate of cardiovascular comorbidities.

中文翻译:

与居住在英国的患有帕金森病的白人个体相比,黑人和亚洲少数民族的临床非运动表型

背景:帕金森病 (PD) 的种族表型差异对于了解 PD 的异质性以及开发生物标志物和临床试验很重要。目的:调查 (i) 黑人、亚洲人和少数民族 (BAME) 和白人 PD 患者之间是否存在基于非运动症状 (NMS) 和合并症的表型差异,以及 (ii) 临床上可用的生物标志物是否有助于区分和解释多样性。方法:这是一项多中心(四个地点,伦敦)、现实生活中的横断面研究,包括 BAME 或白人种族的 PD 患者。主要结果是详细的 NMS 评估,其他测量包括疾病和运动阶段、合并症、社会人口学参数和脑部 MRI 成像。结果:271 名 PD 患者(54 名亚洲人、71 名黑人和 146 名白人)的年龄、性别、和疾病严重程度 (HY)。与白人和亚洲人群相比,黑人患者的病程更短。在黑人(总分和领域“杂项”)和亚洲人(总分和领域“睡眠/疲劳”、情绪/冷漠和感知/幻觉)而不是白人。BAME 人群的动脉高血压患病率较高,而黑人人群的糖尿病患病率较高。与白人和亚洲人相比,大脑 MRI 显示黑人的白质变化更严重。结论:这些发现表明,在 NMS 和运动障碍负担更重、心血管合并症发生率更高的 BAME 人群中,PD 的表型存在差异。与白人和亚洲人群相比,黑人患者的病程更短。在黑人(总分和领域“杂项”)和亚洲人(总分和领域“睡眠/疲劳”、情绪/冷漠和感知/幻觉)而不是白人。BAME 人群的动脉高血压患病率较高,黑人人群的糖尿病患病率较高。与白人和亚洲人相比,大脑 MRI 显示黑人的白质变化更严重。结论:这些研究结果表明,在 NMS 和运动障碍负担更大以及心血管合并症发生率更高的 BAME 人群中,PD 的表型存在差异。与白人和亚洲人群相比,黑人患者的病程更短。在黑人(总分和领域“杂项”)和亚洲人(总分和领域“睡眠/疲劳”、情绪/冷漠和感知/幻觉)而不是白人。BAME 人群的动脉高血压患病率较高,而黑人人群的糖尿病患病率较高。与白人和亚洲人相比,大脑 MRI 显示黑人的白质变化更严重。结论:这些研究结果表明,在 NMS 和运动障碍负担更大以及心血管合并症发生率更高的 BAME 人群中,PD 的表型存在差异。
更新日期:2020-10-20
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