The cellular accumulation of drug delivery systems (DDSs) is a critical parameter to determine the final outcome of cancer chemotherapy. Herein, we designed a red blood cells membrane-based vehicle (RV) and employed it to load both doxorubicin (Dox) and IR 780 (RV/I-D). The photothermal-assisted chemotherapy efficacy of RV/I-D on the treatment of cancer was tested on a prostate cancer model. Excitingly, the results showed that RV/I-D was stable and safe nanoparticles with size at about 100 nm. Moreover, upon the increase of system temperature using photothermal effects of IR780, the drug release of the DDS was accelerated. Above all, the DDS also increased the accumulation of drugs into the Dox-resistant prostate cancer cells (PC-3/Dox) both in vitro and in vivo and showed enhanced anticancer performance.

药物输送系统（DDS）的细胞蓄积是确定癌症化学疗法最终结果的关键参数。在这里，我们设计了一种基于红细胞膜的载体（RV），并使用它来装载阿霉素（Dox）和IR 780（RV / ID）。在前列腺癌模型上测试了RV / ID的光热辅助化学疗法治疗癌症的功效。令人兴奋的是，结果表明RV / ID是稳定且安全的纳米粒子，尺寸约为100 nm。此外，在利用IR780的光热效应提高系统温度后，DDS的药物释放得以加速。最重要的是，在体外和体内，DDS还增加了药物向耐Dox的前列腺癌细胞（PC-3 / Dox）的蓄积 并显示出增强的抗癌性能。