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Modeling Adipogenesis: Current and Future Perspective
Cells ( IF 6 ) Pub Date : 2020-10-20 , DOI: 10.3390/cells9102326
Hisham F. Bahmad , Reem Daouk , Joseph Azar , Jiranuwat Sapudom , Jeremy C. M. Teo , Wassim Abou-Kheir , Mohamed Al-Sayegh

Adipose tissue is contemplated as a dynamic organ that plays key roles in the human body. Adipogenesis is the process by which adipocytes develop from adipose-derived stem cells to form the adipose tissue. Adipose-derived stem cells’ differentiation serves well beyond the simple goal of producing new adipocytes. Indeed, with the current immense biotechnological advances, the most critical role of adipose-derived stem cells remains their tremendous potential in the field of regenerative medicine. This review focuses on examining the physiological importance of adipogenesis, the current approaches that are employed to model this tightly controlled phenomenon, and the crucial role of adipogenesis in elucidating the pathophysiology and potential treatment modalities of human diseases. The future of adipogenesis is centered around its crucial role in regenerative and personalized medicine.

中文翻译:

脂肪形成模型:当前和未来的观点

脂肪组织被认为是在人体中起关键作用的动态器官。脂肪形成是脂肪细胞从脂肪干细胞发育形成脂肪组织的过程。脂肪干细胞的分化远远超出了产生新脂肪细胞的简单目标。实际上,随着当前生物技术的巨大进步,脂肪干细胞的最关键作用仍然是其在再生医学领域的巨大潜力。这篇综述的重点是检查脂肪形成的生理重要性,用于模拟这种严格控制的现象的当前方法,以及脂肪形成在阐明人类疾病的病理生理学和潜在治疗方式中的关键作用。
更新日期:2020-10-20
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