Abstract

In this research, we explored their capacity for Narcissoside antioxidant and anticholinergic, antidiabetic, and anti-acute myeloid leukaemia. Narcissoside’s antioxidant activities were elucidated by the use of various bioanalytical assays. Narcissoside’s radical scavenging activities were evaluated by DPPH^• and ABTS^•+ scavenging activities. On the other hand, IC₅₀ values were calculated for DPPH^•, and ABTS^•+ scavenging, acetylcholinesterase, and α-glucosidase inhibition effects of narcissoside. IC₅₀ values narcissoside, as 11.54 nM for AChE and 65.58 nM for α-glucosidase were calculated with % Activity-[Inhibitory] graphs. Then, ADME/T analysis of narcissoside molecule was performed to calculate the drug becoming parameters.

摘要

在这项研究中，我们探索了它们在水仙苷抗氧化和抗胆碱能、抗糖尿病和抗急性髓性白血病方面的能力。Narcissoside 的抗氧化活性通过使用各种生物分析测定法得到阐明。Narcissoside 的自由基清除活性通过 DPPH ^•和 ABTS ^{• +}清除活性进行评估。另一方面，计算了 DPPH ^•和 ABTS ^{• +清除、乙酰胆碱酯酶和水仙苷的 α-葡萄糖苷酶抑制作用的 IC} ₅₀值。集成电路₅₀水仙苷的值，AChE 为 11.54 nM，α-葡萄糖苷酶为 65.58 nM，使用 % 活性-[抑制] 图计算。然后，对水仙苷分子进行ADME/T分析，计算成药参数。